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Edward K.L. Chan, Ph.D.

Professor, Department of Oral Biology
Professor, Department of Anatomy and Cell Biology

Interdisciplinary Program in Biomedical Sciences (IDP) Affiliations:
Cancer Biology Concentration
Molecular Cell Biology Concentration
Immunology & Microbiology Concentration

(352) 273-8849
PO Box 100424Blue Flame Award- Badge
Gainesville, FL 32610-0424

Shipping Address:
UF Health Science Center
Department of Oral Biology
Room D5-17
1395 Center Dr.
Gainesville, FL 32610



NIH Biosketch
ResearcherID: B-5671-2009

NCBI Bibliography
Google Scholar (H-index)
UFRF Professorship Profile

Research Training & Experience

  • 2004-present: Professor, Department of Anatomy and Cell Biology, College of Medicine, University of Florida
  • 2002-present: Professor, Department of Oral Biology, College of Dentistry, University of Florida
  • 1997-2002: Associate Professor, Department of Molecular & Experimental Medicine, The Scripps Research Institute, La Jolla, California
  • 1991-2002: Director, DNA Core Laboratory for Structural Analysis, The Scripps Research Institute, La Jolla, California
  • 1984-1996: From Research Fellow to Assistant Member, The Scripps Research Institute, La Jolla, California
  • 1984: Ph.D. in Medical Science, University of Calgary, Calgary, Canada
  • 1980: M.S. in Clinical Chemistry, University of Calgary, Calgary, Canada
  • 1976: B.S. in Biochemistry, University of British Columbia, Vancouver, Canada

Teaching Responsibilities

Director, GMS5905 / DEN8290: RNA interference and microRNAs: from advances in cell biology to therapeutic applications in the treatment of human diseases

DEN 6128: Structure and Function of Body System II: Host Defenses, lecture on Autoimmunity and Autoimmune Diseases

DEN 6678: Advanced Oral Medicine: Oral Cancer

DEN 6680: Principles of Craniofacial Biology and Emerging Therapies: Functional Components of Eukaryotic Cells; Oral Carcinoma: Classifications, Incidence, Markers, Current and Future Therapies

DEN 6681: Craniofacial Pathobiology: Hypersensitivity and Autoimmune Diseases

GMS 6421: Advanced Cell Biology: MicroRNAs in Innate Immunity and Cancer Cell Biology

Active Professional Service

Vice Chair (2005-2010), Treasurer (2010-2015), Chair & Treasurer (2015-present) of the Autoantibody Standardization Committee in Rheumatic and Related Disorders of the International Union of Immunological Societies (IUIS) –

International Consensus on ANA Patterns (ICAP) coordinator –

Selected Publications | Selected Chapters, Reviews, & Editorials | Books


Harrandah, A., Fitzpatrick, S.G., Smith, M.H., Wang, D., Cohen, D.M., and Chan, E.K. MicroRNA-375 as a Biomarker for Malignant Transformation in Oral Lesions. Oral Surg Oral Med Oral Pathol Oral Radiol. 122(6):743-752.e1.

Calise, S.J., Purich, D.L., Nguyen, T., Saleem, D.A., Krueger, C., Yin, J.D., and Chan, E.K.Rod and ring’ formation from IMP dehydrogenase is regulated through the one-carbon metabolic pathway. J Cell Sci. 129(15):3042-52.

Chukkapalli, S., Rivera-Kweh, M., Gehlot, P., Velsko, I., Bhattacharyya, I., Calise, S.J., Satoh, M., Chan, E.K., Holoshitz, J., and Kesavalu, L. Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice. Arthritis Res Ther. 18(1):161.

Chan, E.K., Damoiseaux, J., de Melo Cruvinel, W., Carballo, O.G., Conrad, K., Francescantonio, P.L., Fritzler, M.J., Garcia de la Torre, I., Herold, M., Mimori, T., Satoh, M., von Mühlen, C.A., and Andrade, L.E. Report on the second International Consensus on ANA Pattern (ICAP) workshop in Dresden 2015. Lupus. 25(8):797-804.

Conrad, K., Andrade, L.E., Chan, E.K., Mahler, M., Meroni, P.L., Pruijn, G.J., Steiner, G., and Shoenfeld, Y. From autoantibody research to standardized diagnostic assays in the management of human diseases – report of the 12th Dresden Symposium on Autoantibodies. Lupus. 25(8):787-96.

Dinse, G.E., Jusko, T.A., Whitt, I.Z., Co, C.A., Parks, C.G., Satoh, M., Chan, E.K., Rose, K.M., Walker, N.J., Birnbaum, L.S., Zeldin, D.C., Weinberg, C.R., and Miller, F.W. Associations between Selected Xenobiotics and Antinuclear Antibodies in the National Health and Nutrition Examination Survey, 1999-2004. Environ Health Perspect. 124(4):426-36.


Nahid, M.A., Satoh, M., and Chan, E.K. Interleukin 1β-Responsive MicroRNA-146a Is Critical for the Cytokine-Induced Tolerance and Cross-Tolerance to Toll-Like Receptor Ligands. J Innate Immun. 7:428-40.

Keppeke, G.D., Calise, S.J., Chan, E.K., and Andrade, L.E. Assembly of IMPDH2-based, CTPS-based, and mixed rod/ring structures is dependent on cell type and conditions of induction. J Genet Genomics 42(6):287-299.

Keppeke, G.D., Andrade, L.E., Grieshaber, S.S., and Chan, E.K. Microinjection of specific anti-IMPDH2 antibodies induces disassembly of cytoplasmic rods/rings that are primarily stationary and stable structures. Cell Biosci. 5:1.

Jung, H.M., Benarroch, Y., and Chan, E.K. Anti-cancer drugs reactivate tumor suppressor miR-375 expression in tongue cancer cells. J Cell Biochem. 116:836-43.

Libório-Kimura, T.N., Jung, H.M., and Chan, E.K. miR-494 represses HOXA10 expression and inhibits cell proliferation in oral cancer. Oral Oncol. 51:151-7.

Peng, B., Lei, N., Chai, Y., Chan, E.K., and Zhang, J.Y. CIP2A regulates cancer metabolism and CREB phosphorylation in non-small cell lung cancer. Mol Biosyst. 11:105-14.


Ceribelli, A., Fredi, M., Taraborelli, M., Cavazzana, I., Tincani, A., Selmi, C., Chan, J.Y., Chan, E.K., Satoh, M., and Franceschini, F. Prevalence and clinical significance of anti-MDA5 antibodies in European patients with polymyositis/dermatomyositis. Clin Exp Rheumatol. 32:891-7.

Parks, C.G., Miller, F.W., Satoh, M., Chan, E.K., Andrushchenko, Z., Birnbaum, L.S., Jusko, T.A., Kissling, G.E., Patel, M.D., Rose, K.M., Weinberg, C., Zeldin, D.C., and Sandler, D.P. Reproductive and hormonal risk factors for antinuclear antibodies (ANA) in a representative sample of U.S. women. Cancer Epidemiol Biomarkers Prev. 23:2492-502.

Mahler, M., Satoh, M., Hudson, M., Baron, M., Chan, J.Y., Chan, E.K., Wick, J., Fritzler, M.J., and the Canadian Scleroderma Research Group. Autoantibodies to the Rpp25 component of the Th/To complex are the most common antibodies in patients with systemic sclerosis without antibodies detectable by widely available commercial tests. J Rheumatol. 41:1334-43.

Jung, H.M., Phillips, B.L., and Chan, E.K. miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3ζ. Mol Cancer. 13:80.

Keppeke, G.D., Satoh, M., Ferraz, M.L., Chan, E.K., and Andrade, L.E. Temporal evolution of human autoantibody response to cytoplasmic rods and rings structure during anti-HCV therapy with ribavirin and interferon-α. Immunol Res. 60:38-49.

Dominguez-Gutierrez, P.R., Ceribelli, A., Satoh, M., Sobel, E.S., Reeves, W.H., and Chan, E.K. Reduced levels of CCL2 and CXCL10 in systemic lupus erythematosus patients under treatment with prednisone, mycophenolate mofetil, or hydroxychloroquine, except in a high STAT1 subset. Arthritis Res Ther. 16:R23.

Dominguez-Gutierrez, P.R., Ceribelli, A., Satoh, M., Sobel, E.S., Reeves, W.H., and Chan, E.K. Elevated signal transducers and activators of transcription 1 correlates with increased C-C motif chemokine ligand 2 and C-X-C motif chemokine 10 levels in peripheral blood of patients with systemic lupus erythematosus. Arthritis Res Ther. 16:R20.

Calise, S.J., Carcamo, W.C., Krueger, C., Yin, J.D., Purich, D.L., and Chan, E.K. Glutamine deprivation initiates reversible assembly of mammalian rods and rings. Cell Mol Life Sci. 71:2963-73.

Dominguez-Gutierrez, P.R., Ceribelli, A., Satoh, M., Sobel, E.S., Reeves, W.H., and Chan, E.K. Positive Correlation of STAT1 and miR-146a with Anemia in Patients with Systemic Lupus Erythematosus. J Clin Immunol. 34:171-80.

Agmon-Levin, N., Damoiseaux, J., Kallenberg, C., Sack, U., Witte, T., Herold, M., Bossuyt,  X., Musset, L., Cervera, R., Plaza-Lopez, A., Dias, C., Sousa, M.J., Radice, A., Eriksson, C., Hultgren, O., Viander, M., Khamashta, M., Regenass, S., Andrade, L.E., Wiik, A., Tincani, A., Rönnelid, J., Bloch, D.B., Fritzler, M.J., Chan, E.K., Garcia De La Torre, I., Konstantinov, K.N., Lahita, R., Wilson, M., Vainio, O., Fabien, N., Sinico, R.A., Meroni, P., and Shoenfeld, Y. International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies. Ann Rheum Dis. 73:17-23.


Meroni, P.L., Chan, E.K., Tincani, A., Garcia de la Torre, I., and Andrade, L.E. Antinuclear antibody test: when to order? Am J Med. 126:e17.

Mahler, M., Gascon, C., Patel, S., Ceribelli, A., Fritzler, M.J., Swart, A., Chan E.K., and Satoh, M. Rpp25 is a major target of autoantibodies to the Th/To complex as measured by a novel chemiluminescent assay. Arthritis Res Ther. 15:R50.

Petri, M.H., Satoh, M., Martin-Marquez, B.T., Vargas-Ramírez, R., Jara, L.J., Saavedra, M.A., Cruz-Gonzalez, C., Andrade-Ortega, L., Vera-Lastra, O., Salazar-Páramo, M., Prieto-Parra, R.E., Gonzalez-Lopez, L., Gamez-Nava, J.I., Ramírez-Sánchez, H.U., Chan, J.Y., Ross, S.J., Chan, E.K., and Vázquez-Del Mercado, M. Implications in the difference of anti-Mi-2 and -p155/140 autoantibody prevalence in two dermatomyositis cohorts from Mexico City and Guadalajara. Arthritis Res Ther. 15:R48.

Jung, H.M., Patel, R.S., Phillips, B.L., Wang, H., Cohen, D.M., Reinhold, W.C., Chang, L.J., Yang, L.J., and Chan, E.K. Tumor suppressor miR-375 regulates MYC expression via repression of CIP2A coding sequence through multiple miRNA-mRNA interaction. Mol Biol Cell. 24:1638-48.

Nahid, M.A., Yao, B., Dominguez-Gutierrez, P.R., Kesavalu, L., Satoh, M., and Chan, E.K. Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212. J. Immunol. 190:1250-63.

Carcamo, W.C., Ceribelli, A., Calise, S.J., Krueger, C., Liu, C., Daves, M., Villalta, D., Bizzaro, N., Satoh, M., and Chan, E.K. Differential Reactivity to IMPDH2 by Anti-rods/rings Autoantibodies and Unresponsiveness to Pegylated Interferon-alpha/Ribavirin Therapy in US and Italian HCV Patients. J Clin Immunol. 33:420-6.

Laine, A., Sihto, H., Come, C., Rosenfeldt, M.T., Zwolinska, A., Niemelä, M., Khanna, A., Chan, E.K., Kähäri, V.-M., Kellokumpu-Lehtinen, P.-L., Sansom, O., Evan, G.I., Junttila, M.R., Ryan, K.M., Marine, J.-C., Joensuu, H., and Westermarck, J. Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Cancer Discov. 3:182-97.


Yao, B., La, L.B., Chen, Y.C., Chang, L.J., and Chan, E.K. Defining a new role of GW182 in maintaining miRNA stability. EMBO Rep. 13:1102-8.

Keppeke, G.D., Nunes, E., Ferraz, M.L., Silva, E.A., Granato, C., Chan, E.K., and Andrade, L.E. Longitudinal Study of a Human Drug-Induced Model of Autoantibody to Cytoplasmic Rods/Rings following HCV Therapy with Ribavirin and Interferon-α. PLoS One 7:e45392.

Jung, H.M., Phillips, B.L., Patel, R.S., Cohen, D.M., Jakymiw, A., Kong, W.W., Cheng, J.Q., and Chan, E.K. Keratinization-associated miR-7 and miR-21 regulate tumor suppressor reversion-inducing-cysteine-rich protein with kazal motifs (RECK) in oral cancer. J Biol Chem. 287:29261-72.

Ceribelli, A., Satoh, M., and Chan, E.K. A new immunoprecipitation-real time quantitative PCR assay for anti-Th/To and anti-U3RNP antibody detection in systemic sclerosis. Arthritis Res Ther. 14:R128.

Ceribelli, A., Fredi, M., Taraborelli, M., Cavazzana, I., Franceschini, F., Quinzanini, M., Tincani, A., Ross, S.J., Chan, J.Y., Pauley, B.A., Chan, E.K., and Satoh, M. Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis. Arthritis Res Ther. 14:R97.

Satoh, M., Chan, J.Y., Ross, S.J., Li, Y., Yamasaki, Y., Yamada, H., Vazquez-Del Mercado, M., Petri, M., Jara, L.J., Saavedra, M.A., Cruz-Reyes, C., Sobel, E.S., Reeves, W.H., Ceribelli, A., and Chan, E.K. Autoantibodies to transcription intermediary factor (TIF)1beta associated with dermatomyositis. Arthritis Res Ther. 14:R79.

Ventelä, S., Côme, C., Mäkelä, J.A., Hobbs, R.M., Mannermaa, L., Kallajoki, M., Chan, E.K., Pandolfi, P.P., Toppari, J., and Westermarck, J. CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice. PLoS One 7:e33209.

Satoh, M., Ceribelli, A., and Chan, E.K. Role of environmental factors in autoantibody production – importance of a detailed analysis in a small cohort. Arthritis Res Ther. 14:109.

Satoh, M., Ceribelli, A., and Chan, E.K. Common pathways of autoimmune inflammatory myopathies and genetic neuromuscular disorders. Clin Rev Allergy Immunol. 42:16-25.

Satoh, M., Chan, E.K., Ho, L.A., Rose, K.M., Parks, C.G., Cohn, R.D., Jusko, T.A., Walker, N.J., Germolec, D.R., Whitt, I.Z., Crockett, P.W., Pauley, B.A., Chan, J.Y., Ross, S.J., Birnbaum, L.S., Zeldin, D.C., and Miller, F.W. Prevalence and sociodemographic correlates of antinuclear antibodies in the United States. Arthritis Rheum. 64:2319-27.

Covini, G., Carcamo, W.C., Bredi, E., von Mühlen, C.A., Colombo, M., and Chan, E.K. Cytoplasmic rods and rings autoantibodies developed during pegylated interferon and ribavirin therapy in patients with chronic hepatitis C. Antivir Ther. 17:805-11.


Carcamo, W.C., Satoh, M., Kasahara, H., Terada, N., Hamazaki, T., Chan, J.Y., Yao, B., Tamayo, S., Covini, G., von Mühlen, C.A., and Chan, E.K. Induction of cytoplasmic rods and rings structures by inhibition of the CTP and GTP synthetic pathway in mammalian cells. PLoS One 6:e29690.

Patel, R.S., Jakymiw, A., Yao, B., Pauley, B.A., Carcamo, W.C., Katz, J., Cheng, J.Q., and Chan, E.K. High resolution of microRNA signatures in human whole saliva. Arch. Oral Biol. 56:1506-13.

Satoh, M., Vázquez del Mercado, M., Krzyszczak, M.E., Li, Y., Ceribelli, A., Burlingame, R.W., Webb, T.T., Sobel, E.S., Reeves, W.H., and Chan, E.K. Coexistence of anti-RNA polymerase III and anti-U1RNP antibodies in patients with SLE – Two cases without features of scleroderma. Lupus 21:68-74.

Nahid, M.A., Satoh, M., and Chan, E.K. Mechanistic role of miR-146a in endotoxin-induced differential cross-regulation of TLR signaling. J Immunol. 186:1723-34.

Nahid, M.A., Rivera, M., Lucas, A., Chan, E.K., and Kesavalu, L. Polymicrobial infection with periodontal pathogens specifically enhances miR-146a in ApoE-/- mice during experimental periodontal disease. Infection Immun. 79:1597-605.

Satoh, M., Bjerkås, I., Haugarvoll, E., Chan, E.K., Szabo, N.J., Jirillo, E., Poppe, T.T., Sveier, H., Tørud, B., and Koppang, E.O. Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in farmed Atlantic salmon. Fish Shellfish Immunol. 30:1080-6.

Yao, B., Li, S., Lian, S.L., Fritzler, M.J., and Chan, E.K. Mapping of Ago2-GW182 functional interactions. Methods Mol. Biol. 725:45-62.

Satoh, M., Krzyszczak, M.E., Li, Y., Ceribelli, A., Ross, S.J., Chan, E.K., Segal, M.S., Bubb, M.R., Sobel, E.S., and Reeves, W.H. Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical study. Arthritis Res. Ther. 13:R73.

Satoh, M., Chan, J.Y., Ross, S.J., Ceribelli, A., Cavazzana, I., Franceschini, F., Li, Y., Reeves, W.H., Sobel, E.S., and Chan, E.K. Autoantibodies to survival of motor neuron complex in patients with polymyositis: Immunoprecipitation of D, E, F, and G proteins without other components of small nuclear ribonucleoproteins. Arthritis Rheum. 63:1972-8.

Pauley, K.M., Stewart, C.M., Gauna A.E., Dupre, L.C., Kuklani, R., Chan, A.L., Pauley, B.A., Reeves, W.H., Chan, E.K., and Cha, S. Altered miR-146a expression in Sjögren’s syndrome and its functional role in innate immunity. European J. Immunol. 41:2029-39.

Ceribelli, A., Krzyszczak, M.E., Li, Y., Ross, S.J., Chan, J.Y.F., Chan, E.K., Burlingame, R., Webb, T.T., Bubb, M.R., Sobel, E.S., Reeves, W.H., and Satoh, M. Atypical clinical presentation of a subset of patients with anti-RNA polymerase III – non-scleroderma cases associated with dominant RNA polymerase I reactivity and nucleolar staining. Arthritis Res. Ther. 13:R119.

Pauley, K.M., Gauna A.E., Grichtchenko, I.I., Chan, E.K., and Cha, S. A secretagogue-small interfering RNA conjugate confers resistance to cytotoxicity in a cell model of Sjögren’s syndrome. Arthritis Rheum. 63:3116-25.

Krzyszczak, M.E., Li, Y., Ross, S.J., Ceribelli, A., Chan, E.K., Bubb, M.R., Sobel, E.S., Reeves, W.H., and Satoh, M. Gender and ethnicity differences in the prevalence of scleroderma-related autoantibodies. Clin. Rheumatol. 30:1333-9.

Yao, B., Li. S., Jung, H.M., Lian, S.L., Abadal, G.X., Han, F., Fritzler, M.J., and Chan, E.K. Divergent GW182 functional domains in the regulation of translational silencing. Nucleic Acids Res. 39:2534-47. PMC3074120.

Ceribelli, A., Tincani, A., Cavazzana, I., Franceschini, F., Cattaneo, R., Pauley, B.A., Chan, J.Y.F., Chan, E.K., and Satoh, M. Anti-argonaute2 (Ago2/Su) and -Ro antibodies identified by immunoprecipitation in primary anti-phospholipid syndrome (PAPS). Autoimmunity 44:90-7.


Vázquez-Del Mercado, M., Sánchez Orozco, L.V., Pauley, B.A., Chan, J.Y.F., Chan, E.K., Panduro, A., Maldonado González, M., Jimenez-Luevanos, M.A., Martin Márquez, B.T., Palafox-Sanchez, C.A., Dávalos-Rodríguez, I.P., Salazar-Páramo, M., González Lopez, L., Gámez Nava, J.I., and Satoh, M. Autoantibodies to a miRNA-binding protein Argonaute 2 (Su antigen) in patients with hepatitis C virus infection. Clin. Exp. Rheumatol. 28:842-8.

Katz, J., Jakymiw, A., Ducksworth, M.K., Stewart, C.M., Bhattacharyya, I., Cha, S., and Chan, E.K. CIP2A expression and localization in oral carcinoma and dysplasia. Cancer Biology & Therapy 10:694-699.

Ceribelli, A., Cavazzana, I., Franceschini, F., Airò, P., Tincani, A., Cattaneo, R., Pauley, B.A., Chan, E.K., and Satoh, M. Anti-Th/To are common anti-nucleolar autoantibodies in Italian scleroderma patients. J. Rheumatol. 37:2071-5.

Jakymiw, A., Patel, R.S., Deming, N., Bhattacharyya, I., Shah, P., Lamont, R.J., Stewart, C., Cohen, D., and Chan, E.K. Overexpression of dicer as a result of reduced let-7 microRNA levels contributes to increased cell proliferation of oral cancer cells. Genes, Chromosomes and Cancer 49:540-59.

Pauley, K.M., Satoh, M., Pauley, B.A., Dominguez-Gutierrez, P.R., Wallet, S.M., Holliday, L.S., Cha, S., Reeves, W.H., and Chan, E.K. Formation of GW/P bodies as marker for microRNA-mediated regulation of innate immune signaling in THP-1 cells. Immunol. Cell Biol. 88:205-12.

Vázquez-Del Mercado, M., Palafox-Sánchez, C.A., Muñoz-Valle, J.F., Orozco-Barocio, G., Oregon Romero, E., Navarro Hernández, R.E., Salazar-Páramo, M., Chan, J.Y.F., Chan, E.K., and Satoh, M. High prevalence of autoantibodies to RNA helicase A in Mexican patients with systemic lupus erythematosus. Arthritis Res. Ther. 12:R6.

Pereira, D.B., Sannes, T., Dodd, S.M., Jensen, S.E., Morgan, L.S., and Chan, E.K. Life stress, negative mood states, and antibodies to heat shock protein 70 in endometrial cancer. Brain, Behavior, and Immunity 24:210-4.


Ostrov, D.A., Magis, A.T., Wronski, T.J., Chan, E.K., Toro, E.J., Donatelli, R.E., Sajek, K., Haroun, I.N., Nagib, M.I. Piedrahita, A., Harris, A., and Holliday, L.S. Identification of enoxacin as an inhibitor of osteoclast formation and bone resorption by structure-based virtual screening. J. Med. Chem. 52:5144-5151.

Kakumanu, P., Sobel, E.S., Narain, S., Li, Y., Akaogi, J., Yamasaki, Y., Segal, M.S., Hahn, P.C., Chan, E.K., Reeves, W.H., and Satoh, M. Citrulline-dependence of anti-CCP antibodies in SLE as a marker of deforming/erosive arthritis. J. Rheumatol. 36:2682-90.

Nahid, M.A., Pauley, K.M., Satoh, M., and Chan, E.K. miR-146a is critical for endotoxin-induced tolerance: implication on innate immunity. J. Biol. Chem. 284:34590-34599.

Brucato, A., Grava, C., Bortolati, M., Ikeda, K., Milanesi, O., Cimaz, R., Ramoni, V., Vignati, G., Martinelli, S., Sadou, Y., Borghi, A., Tincani, A., Chan, E.K., and Ruffatti, A. Congenital Heart Block not associated with anti-Ro/La antibodies: comparison with anti-Ro/La-positive cases. J. Rheumatol. 36:1744-8.

Lian, S.L., Li. S., Abadal, G.X., Pauley, B.A., Fritzler, M.J., and Chan, E.K. The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing. RNA 15:804-13.

Moser, J.J., Chan, E.K., and Fritzler, M.J. Optimization of immunoprecipitation-western blot analysis in detecting GW182-associated components of GW/P Bodies. Nat Protoc. 4:674-85. PMC2797048.

Llanos, C., Chan, E.K., Li, S., Abadal, G.X., Izmirly, P., Byrne, C., Clancy, R.M., and Buyon, J.P. Antibody reactivity to α-enolase in mothers of children with congenital heart block. J. Rheumatol. 36:565-9.

Palafox-Sánchez, C.A., Satoh, M., Chan, E.K., Carcamo, W.C., Muñoz-Valle, J.F., Orozco-Barocio, G., Oregón-Romero, E., Navarro-Hernández, R.E., Salazar-Páramo, M., Castañeda, A.C., and Vázquez-Del Mercado, M. Reduced IgG anti-snRNPs autoantibody production in SLE patients with positive IgM anti-cytomegalovirus antibodies. Arthritis Res. Ther. 11:R27.

Nozawa, K., Ikeda, K., Satoh, M., Reeves, W.H., Stewart, C., Li, Y.C., Yen, T.J., Rios, R.M., Takamori, K., Ogawa, H., Sekigawa, I., Takasaki, Y., and Chan, E.K. Autoantibody to NA14 is an independent marker primarily for Sjögren’s Syndrome. Frontiers Biosci. 14:3733-3739.

Bulosan, M., Pauley, K.M., Yo, K., Chan, E.K., Katz, J., Peck, A.B., and Cha, S. Inflammatory caspases are critical for enhanced cell death in the target tissue of Sjögren’s Syndrome prior to disease onset. Immunol. Cell Biol. 87:81-90.

Nozawa, K., Fritzler, M.J., Takasaki, Y., Wood, M.R., and Chan, E.K. Co-clustering of Golgi complex and other cytoplasmic organelles to crescentic region of half-moon nuclei during apoptosis. Cell Biol. Int. 33:148-157.


Li, S., Lian, S.L., Moser, J.J., Fritzler, M.L., Fritzler, M.J., Satoh, M., and Chan, E.K. Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2 mediated silencing. J. Cell Sci. 121:4134-44.

Pauley, K.M., Satoh, M., Chan, A.L., Bubb, M.R., Reeves, W.H., and Chan, E.K. Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arth. Res. Ther. 10:R101.


Lian, S., Fritzler, M.J., Katz, J., Hamazaki, T., Terada, N., Satoh, M., and Chan, E.K. Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies. Mol. Biol. Cell 18:3375-87. Expert Reviews written by Herrera-Esparza et al, 2008

Zhang, J.Y., Megliorino, R., Peng, X.X., Tan, E.M., Chen, Y., and Chan, E.K. Antibody detection using tumor-associated antigen mini-array in immunodiagnosing human hepatocellular carcinoma. J. Hepatol. 46:107-114.


Ikeda, K., Satoh, M., Pauley, K.M., Fritzler, M.J., Reeves, W.H., and Chan, E.K. Detection of the argonaute protein Ago2 and microRNAs in the RNA induced silencing complex (RISC) using a monoclonal antibody. J. Immunol. Methods 317:38-44.

Pauley, K.M., Eystathioy, T., Jakymiw, A., Hamel J.C., Fritzler, M.J., and Chan, E.K. Formation of GW bodies is a consequence of miRNA genesis. EMBO Reports 7:904-910.

Jakymiw, A., Ikeda, K., Fritzler, M.J., Reeves, W.H., Satoh, M., and Chan, E.K. Autoimmune targeting of key components of RNA interference. Arthritis Res. Ther. 8:R87.

Lian, S., Jakymiw, A., Eystathioy, T., Hamel, J.C., Fritzler, M.J., and Chan, E.K. GW bodies, microRNAs and the cell cycle. Cell Cycle 5:242-5.


Jakymiw, A., Lian, S., Eystathioy, T., Li, S., Satoh, M., Hamel J.C., Fritzler, M.J., and Chan, E.K. Disruption of GW bodies impairs mammalian RNA Interference. Nature Cell Biol. 7:1267-74.


Selected Chapters, Reviews, & Editorials


Satoh, M., Tanaka, S., Ceribelli, A., Calise, S.J., and Chan, E.K. A Comprehensive Overview on Myositis-Specific Antibodies: New and Old Biomarkers in Idiopathic Inflammatory Myopathy. Clin Rev Allergy Immunol. [Epub ahead of print]

Chan, E.K., Damoiseaux, J., Carballo, O.G., Conrad, K., de Melo Cruvinel, W., Francescantonio, P.L., Fritzler, M.J., Garcia-De La Torre, I., Herold, M., Mimori, T., Satoh, M., von Mühlen, C.A., and Andrade, L.E. Report of the First International Consensus on Standardized Nomenclature of Antinuclear Antibody HEp-2 Cell Patterns 2014-2015. Front Immunol. 6:412.

Satoh, M., Tanaka, S., and Chan, E.K. The uses and misuses of multiplex autoantibody assays in systemic autoimmune rheumatic diseases. Front Immunol. 6:181.

Fredenburg, K.M. and Chan, E.K. Our journey from the study of human autoantibodies to the microRNA world. Front Immunol. 6:110.

Calise, S.J., Keppeke, G.D., Andrade, L.E., and Chan, E.K. Anti-rods/rings: a human model of drug-induced autoantibody generation. Front Immunol. 6:41.


Calise, S.J., Carcamo, W.C., Ceribelli, A., Dominguez, Y., Satoh, M., and Chan, E.K. Antibodies to rods and rings. In Autoantibodies (Shoenfeld, Y., Meroni, P.L., Gershwin, M.E., Eds.), pp. 161-168. Elsevier Science, Third Edition.

Carcamo, W.C., Calise, S.J., von Mühlen, C.A., Satoh, M., and Chan, E.K. Molecular cell biology and immunobiology of mammalian rod/ring structures. Int Rev Cell Mol Biol. 308:35-74.


Chan, E.K., Ceribelli, A., and Satoh, M. MicroRNA-146a in autoimmunity and innate immune responses. Ann. Rheum. Dis. 72:ii90-ii95.

Chan, E.K. and Fritzler, M.J. Introduction – The GW body story as an example of autoantibodies with significant impacts to molecular cell biology. In Ten Years of Progress in GW/P Body Research, edited by E.K.L. Chan and M.J. Fritzler, Adv Exp Med Biol, 768:1-4.

Fritzler, M.J. and Chan, E.K. The discovery of GW bodies. In Ten Years of Progress in GW/P Body Research, edited by E.K.L. Chan and M.J. Fritzler, Adv Exp Med Biol, 768:5-21.

Satoh, M., Chan, J.Y., Ceribelli, A., Vazquez del-Mercado, M., and Chan, E.K. Autoantibodies to Argonaute 2 (Su antigen). In Ten Years of Progress in GW/P Body Research, edited by E.K.L. Chan and M.J. Fritzler, Adv Exp Med Biol, 768:45-59.

Yao, B., Li, S., and Chan, E.K. Function of GW182 and GW bodies in siRNA and miRNA pathways. In Ten Years of Progress in GW/P Body Research, edited by E.K.L. Chan and M.J. Fritzler, Adv Exp Med Biol, 768:71-96.

Moser, J.J., Chan, E.K., and Fritzler, M.J. An SNP in the trinucleotide repeat region of the GW182/TNRC6A gene maps to a major TNGW1 autoepitope in patients with autoantibodies to GW182. In Ten Years of Progress in GW/P Body Research, edited by E.K.L. Chan and M.J. Fritzler, Adv Exp Med Biol, 768:243-59.


Chan, E.K., Ceribelli, A., and Nahid, M.A. The role of miRNAs in the regulation of immunological functions and the prevention of autoimmunity. In: K. Conrad, E.K.L. Chan, M.J. Fritzler, R.L. Humbel, P.L. Meroni, Y. Shoenfeld (eds), From Prediction to Prevention of Autoimmune Diseases. Autoantigens, Autoantibodies and Autoimmunity series. Volume 7. Proceedings 10th Dresden Symposium on Autoantibodies. Pabst Science Publishers, Lengerich, Germany, pp253-266.

Ceribelli, A., Nahid, M.A., Satoh, M., and Chan, E.K. MicroRNAs in rheumatoid arthritis. FEBS Letters 585, pp. 3667-3674.

Ceribelli, A., Yao, B., Dominguez-Gutierrez, P.R., and Chan, E.K. Editorial: Lupus T cells switched on by DNA hypomethylation via microRNAs? Arthritis Rheum. 63:1177-81.

Ceribelli, A., Yao, B., Dominguez-Gutierrez, P.R., Nahid, M.A., Satoh, M., and Chan, E.K. MicroRNAs in systemic rheumatic diseases. Arthritis Res. Ther. 13:229.

Nahid, M.A., Satoh, M., and Chan, E.K. MicroRNA in TLR signaling and endotoxin tolerance. Cell. Mol. Immunol. 8:388-403.


Chan, E.K. Autoantibodies to multiple components of the microRNA pathway and aberrant microRNA expression in autoimmune diseases. In: Jack D. Keene (ed), Autoantibodies and Autoimmunity, MBL, Tokyo, Japan, pp45-59.

Satoh, M., Fritzler, M.J., and Chan, E.K. Anti-histone and anti-spliceosomal antibodies. In Systemic Lupus Erythematosus, 5th ed. edited by Robert G. Lahita. Academic Press, San Diego, Chapter 16, pp. 275- 292.


Katz, J. and Chan, E.K. Commentary: Cell cycle proteins to monitor cancer of salivary glands. Cancer Biol. Ther. 8:159-160.

Satoh, M., Vázquez-Del Mercado, M., and Chan, E.K. Clinical interpretation of antinuclear antibody tests in systemic rheumatic diseases. Mod. Rheum. 19:219-28.

Chan, E.K., Satoh, M., and Pauley, K.M. Editorial: Contrast in aberrant microRNA expression in SLE and RA: Is miR-146 all we need? Arthritis Rheum. 60:912-915.

Pauley, K.M., Cha, S., and Chan, E.K. MicroRNA in autoimmunity and autoimmune diseases. J. Autoimmunity 32:189-194.


Pauley, K.M. and Chan, E.K. MicroRNAs and their emerging roles in immunology. In: Noel R. Rose (ed), The Year in Immunology, Ann. N.Y. Acad. Sci. 1143:226-39.


Jakymiw, A., Pauley, K.M., Li, S., Lian, S., Ikeda, K., Eystathioy, T., Satoh, M., Fritzler, M.J., and Chan, E.K. The role of GW/P-bodies in RNA processing and silencing. J. Cell Sci., 120:1317-1323.



Ten Years of Progress in GW/P Body Research, Dr. Edward K.L. Chan and Dr. Marvin J. Fritzler, Eds.