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Publications

Selected Publications – Original Research

2014

Libório-Kimura, T.N., Jung, H.M., and Chan, E.K. miR-494 represses HOXA10 expression and inhibits cell proliferation in oral cancer. Oral Oncol. [Epub ahead of print]

highlyaccessedJung, H.M., Phillips, B.L., and Chan, E.K. miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3ζ. Mol Cancer. 13:80.

Calise, S.J., Carcamo, W.C., Krueger, C., Yin, J.D., Purich, D.L., and Chan, E.K. Glutamine deprivation initiates reversible assembly of mammalian rods and rings. Cell Mol Life Sci. 71:2963-73.

Dominguez-Gutierrez, P.R., Ceribelli, A., Satoh, M., Sobel, E.S., Reeves, W.H., and Chan, E.K. Reduced levels of CCL2 and CXCL10 in systemic lupus erythematosus patients under treatment with prednisone, mycophenolate mofetil, or hydroxychloroquine, except in a high STAT1 subset. Arthritis Res Ther. 16:R23.

Dominguez-Gutierrez, P.R., Ceribelli, A., Satoh, M., Sobel, E.S., Reeves, W.H., and Chan, E.K. Elevated signal transducers and activators of transcription 1 correlates with increased C-C motif chemokine ligand 2 and C-X-C motif chemokine 10 levels in peripheral blood of patients with systemic lupus erythematosus. Arthritis Res Ther. 16:R20.

2013

Dominguez-Gutierrez, P.R., Ceribelli, A., Satoh, M., Sobel, E.S., Reeves, W.H., and Chan, E.K. Positive Correlation of STAT1 and miR-146a with Anemia in Patients with Systemic Lupus Erythematosus. J Clin Immunol. 34:171-80.

Mahler, M., Gascon, C., Patel, S., Ceribelli, A., Fritzler, M.J., Swart, A., Chan, E.K., and Satoh, M. Rpp25 is a major target of autoantibodies to the Th/To complex as measured by a novel chemiluminescent assay. Arthritis Res Ther. 15:R50.

Petri, M.H., Satoh, M., Martin-Marquez, B.T., Vargas-Ramírez, R., Jara, L.J., Saavedra, M.A., Cruz-Gonzalez, C., Andrade-Ortega, L., Vera-Lastra, O., Salazar-Páramo, M., Prieto-Parra, R.E., Gonzalez-Lopez, L., Gamez-Nava, J.I., Ramírez-Sánchez, H.U., Chan, J.Y., Ross, S.J., Chan, E.K., and Vázquez-Del Mercado, M. Implications in the difference of anti-Mi-2 and -p155/140 autoantibody prevalence in two dermatomyositis cohorts from Mexico City and Guadalajara. Arthritis Res Ther. 15:R48.

Laine, A., Sihto, H., Come, C., Rosenfeldt, M.T., Zwolinska, A., Niemelä, M., Khanna, A., Chan, E.K., Kähäri, V.M., Kellokumpu-Lehtinen, P.L., Sansom, O.J., Evan, G.I., Junttila, M.R., Ryan, K.M., Marine, J.C., Joensuu, H., and Westermarck, J. Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Cancer Discov. 3:182-97.

Jung, H.M., Patel, R.S., Phillips, B.L., Wang, H., Cohen, D.M., Reinhold, W.C., Chang, L.J., Yang, L.J., and Chan, E.K. Tumor suppressor miR-375 regulates MYC expression via repression of CIP2A coding sequence through multiple miRNA-mRNA interaction. Mol Biol Cell. 24:1638-48.

Nahid, M.A., Yao, B., Dominguez-Gutierrez, P.R., Kesavalu, L., Satoh, M., and Chan, E.K. Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212. J. Immunol., 190:1250-63.

Carcamo, W.C., Ceribelli, A., Calise, S.J., Krueger, C., Liu, C., Daves, M., Villalta, D., Bizzaro, N., Satoh, M., and Chan, E.K. Differential reactivity to IMPDH2 by anti-rods/rings autoantibodies and unresponsiveness to pegylated interferon-alpha/ribavirin therapy in US and Italian HCV patients. J Clin Immunol. 33:420-6.

2012

Yao, B., La, L.B., Chen, Y.C., Chang, L.J., and Chan, E.K. Defining a new role of GW182 in maintaining miRNA stability. EMBO Rep. 13:1102-8.

Keppeke, G.D., Nunes, E., Ferraz, M.L., Silva, E.A., Granato, C., Chan, E.K., and Andrade, L.E. Longitudinal Study of a Human Drug-Induced Model of Autoantibody to Cytoplasmic Rods/Rings following HCV Therapy with Ribavirin and Interferon-α. PLoS One 7:e45392.

Jung, H.M., Phillips, B.L., Patel, R.S., Cohen, D.M., Jakymiw, A., Kong, W.W., Cheng, J.Q., and Chan, E.K. Keratinization-associated miR-7 and miR-21 regulate tumor suppressor reversion-inducing-cysteine-rich protein with kazal motifs (RECK) in oral cancer. J Biol Chem. 287:29261-72.

Ceribelli, A., Satoh, M., and Chan, E.K. A new immunoprecipitation-real time quantitative PCR assay for anti-Th/To and anti-U3RNP antibody detection in systemic sclerosis. Arthritis Res Ther. 14:R128.

Ceribelli, A., Fredi, M., Taraborelli, M., Cavazzana, I., Franceschini, F., Quinzanini, M., Tincani, A., Ross, S.J., Chan, J.Y., Pauley, B.A., Chan, E.K., and Satoh, M. Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis. Arthritis Res Ther. 14:R97.

Satoh, M., Chan, J.Y., Ross, S.J., Li, Y., Yamasaki, Y., Yamada, H., Vazquez-Del Mercado, M., Petri, M., Jara, L.J., Saavedra, M.A., Cruz-Reyes, C., Sobel, E.S., Reeves, W.H., Ceribelli, A., and Chan, E.K. Autoantibodies to transcription intermediary factor (TIF)1beta associated with dermatomyositis. Arthritis Res Ther. 14:R79.

Satoh, M., Ceribelli, A., and Chan, E.K. Role of environmental factors in autoantibody production – importance of a detailed analysis in a small cohort. Arthritis Res Ther. 14:109.

Satoh, M., Ceribelli, A., and Chan, E.K. Common pathways of autoimmune inflammatory myopathies and genetic neuromuscular disorders. Clin Rev Allergy Immunol. 42:16-25.

Satoh, M., Chan, E.K., Ho, L.A., Rose, K.M., Parks, C.G., Cohn, R.D., Jusko, T.A., Walker, N.J., Germolec, D.R., Whitt, I.Z., Crockett, P.W., Pauley, B.A., Chan, J.Y., Ross, S.J., Birnbaum, L.S., Zeldin, D.C., and Miller, F.W. Prevalence and sociodemographic correlates of antinuclear antibodies in the United States. Arthritis Rheum. 64:2319-27.

Covini, G., Carcamo, W.C., Bredi, E., von Mühlen, C.A., Colombo, M., and Chan, E.K. Cytoplasmic rods and rings autoantibodies developed during pegylated interferon and ribavirin therapy in patients with chronic hepatitis C. Antivir Ther. DOI: 10.3851/IMP1993.

2011

Carcamo, W.C., Satoh, M., Kasahara, H., Terada, N., Hamazaki, T., Chan, J.Y., Yao, B., Tamayo, S., Covini, G., von Mühlen, C.A., and Chan, E.K. Induction of cytoplasmic rods and rings structures by inhibition of the CTP and GTP synthetic pathway in mammalian cells. PLoS One 6:e29690.

Patel, R.S., Jakymiw, A., Yao, B., Pauley, B.A., Carcamo, W.C., Katz, J., Cheng, J.Q., and Chan, E.K. High resolution of microRNA signatures in human whole saliva. Arch. Oral Biol., 56:1506-13.

Satoh, M., Vázquez del Mercado, M., Krzyszczak, M.E., Li, Y., Ceribelli, A., Burlingame, R.W., Webb, T.T., Sobel, E.S., Reeves, W.H., and Chan, E.K. Coexistence of anti-RNA polymerase III and anti-U1RNP antibodies in patients with SLE – Two cases without features of scleroderma. Lupus, 21:68-74.

Nahid, M.A., Satoh, M., and Chan, E.K. Mechanistic role of miR-146a in endotoxin-induced differential cross-regulation of TLR signaling. J Immunol. 186:1723-34.

Nahid, M.A., Rivera, M., Lucas, A., Chan, E.K., and Kesavalu, L. Polymicrobial infection with periodontal pathogens specifically enhances miR-146a in ApoE-/- mice during experimental periodontal disease. Infection Immun. 79:1597-605.

Yao, B., Li, S., Lian, S.L., Fritzler, M.J., and Chan, E.K. Mapping of Ago2-GW182 functional interactions. Methods Mol. Biol. 725:45-62.

Satoh, M., Krzyszczak, M.E., Li, Y., Ceribelli, A., Ross, S.J., Chan, E.K., Segal, M.S., Bubb, M.R., Sobel, E.S., and Reeves, W.H. Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical study. Arthritis Res. Ther. 13:R73.

Satoh, M., Chan, J.Y., Ross, S.J., Ceribelli, A., Cavazzana, I., Franceschini, F., Li, Y., Reeves, W.H., Sobel, E.S., and Chan, E.K. Autoantibodies to survival of motor neuron complex in patients with polymyositis: Immunoprecipitation of D, E, F, and G proteins without other components of small nuclear ribonucleoproteins. Arthritis Rheum., 63:1972-8.

Pauley, K.M., Stewart, C.M., Gauna A.E., Dupre, L.C., Kuklani, R., Chan, A.L., Pauley, B.A., Reeves, W.H., Chan, E.K., and Cha, S. Altered miR-146a expression in Sjögren’s syndrome and its functional role in innate immunity. European J. Immunol., 41:2029-39.

Ceribelli, A., Krzyszczak, M.E., Li, Y., Ross, S.J., Chan, J.Y.F., Chan, E.K., Burlingame, R., Webb, T.T., Bubb, M.R., Sobel, E.S., Reeves, W.H., and Satoh, M. Atypical clinical presentation of a subset of patients with anti-RNA polymerase III – non-scleroderma cases associated with dominant RNA polymerase I reactivity and nucleolar staining. Arthritis Res. Ther. 13:R119.

Pauley, K.M., Gauna A.E., Grichtchenko, I.I., Chan, E.K., and Cha, S. A secretagogue-small interfering RNA conjugate confers resistance to cytotoxicity in a cell model of Sjögren’s syndrome. Arthritis Rheum. 63:3116-25.

Krzyszczak, M.E., Li, Y., Ross, S.J., Ceribelli, A., Chan, E.K., Bubb, M.R., Sobel, E.S., Reeves, W.H., and Satoh, M. Gender and ethnicity differences in the prevalence of scleroderma-related autoantibodies. Clin. Rheumatol. 30:1333-9.

Yao, B., Li. S., Jung, H.M., Lian, S.L., Abadal, G.X., Han, F., Fritzler, M.J., and Chan, E.K. Divergent GW182 functional domains in the regulation of translational silencing. Nucleic Acids Res. 39:2534-47. PMC3074120.

Ceribelli, A., Tincani, A., Cavazzana, I., Franceschini, F., Cattaneo, R., Pauley, B.A., Chan, J.Y.F., Chan, E.K., and Satoh, M. Anti-argonaute2 (Ago2/Su) and -Ro antibodies identified by immunoprecipitation in primary anti-phospholipid syndrome (PAPS). Autoimmunity 44:90-7.

2010

Vázquez-Del Mercado, M., Sánchez Orozco, L.V., Pauley, B.A., Chan, J.Y.F., Chan, E.K., Panduro, A., Maldonado González, M., Jimenez-Luevanos, M.A., Martin Márquez, B.T., Palafox-Sanchez, C.A., Dávalos-Rodríguez, I.P., Salazar-Páramo, M., González Lopez, L., Gámez Nava, J.I., and Satoh, M. Autoantibodies to a miRNA-binding protein Argonaute 2 (Su antigen) in patients with hepatitis C virus infection. Clin. Exp. Rheumatol. 28:842-8.

Katz, J., Jakymiw, A., Ducksworth, M.K., Stewart, C.M., Bhattacharyya, I., Cha, S., and Chan, E.K. CIP2A expression and localization in oral carcinoma and dysplasia. Cancer Biology & Therapy 10:694-699.

Ceribelli, A., Cavazzana, I., Franceschini, F., Airò, P., Tincani, A., Cattaneo, R., Pauley, B.A., Chan, E.K., and Satoh, M. Anti-Th/To are common anti-nucleolar autoantibodies in Italian scleroderma patients. J. Rheumatol. 37:2071-5.

Jakymiw, A., Patel, R.S., Deming, N., Bhattacharyya, I., Shah, P., Lamont, R.J., Stewart, C., Cohen, D., and Chan, E.K. Overexpression of dicer as a result of reduced let-7 microRNA levels contributes to increased cell proliferation of oral cancer cells. Genes, Chromosomes and Cancer 49:540-59.

Pauley, K.M., Satoh, M., Pauley, B.A., Dominguez-Gutierrez, P.R., Wallet, S.M., Holliday, L.S., Cha, S., Reeves, W.H., and Chan, E.K. Formation of GW/P bodies as marker for microRNA-mediated regulation of innate immune signaling in THP-1 cells. Immunol. Cell Biol. 88:205-12.

Vázquez-Del Mercado, M., Palafox-Sánchez, C.A., Muñoz-Valle, J.F., Orozco-Barocio, G., Oregon Romero, E., Navarro Hernández, R.E., Salazar-Páramo, M., Chan, J.Y.F., Chan, E.K., and Satoh, M. High prevalence of autoantibodies to RNA helicase A in Mexican patients with systemic lupus erythematosus. Arthritis Res. Ther. 12:R6.

2009

Kakumanu, P., Sobel, E.S., Narain, S., Li, Y., Akaogi, J., Yamasaki, Y., Segal, M.S., Hahn, P.C., Chan, E.K., Reeves, W.H., and Satoh, M. Citrulline-dependence of anti-CCP antibodies in SLE as a marker of deforming/erosive arthritis. J. Rheumatol. 36:2682-90.

Nahid, M.A., Pauley, K.M., Satoh, M., and Chan, E.K. miR-146a is critical for endotoxin-induced tolerance: implication on innate immunity. J. Biol. Chem. 284:34590-34599.

Brucato, A., Grava, C., Bortolati, M., Ikeda, K., Milanesi, O., Cimaz, R., Ramoni, V., Vignati, G., Martinelli, S., Sadou, Y., Borghi, A., Tincani, A., Chan, E.K., and Ruffatti, A. Congenital Heart Block not associated with anti-Ro/La antibodies: comparison with anti-Ro/La-positive cases. J. Rheumatol. 36:1744-8.

Lian, S.L., Li. S., Abadal, G.X., Pauley, B.A., Fritzler, M.J., and Chan, E.K. The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing. RNA 15:804-13.

Moser, J.J., Chan, E.K., and Fritzler, M.J. Optimization of immunoprecipitation-western blot analysis in detecting GW182-associated components of GW/P Bodies. Nat Protoc. 4:674-85. PMC2797048.

Llanos, C., Chan, E.K., Li, S., Abadal, G.X., Izmirly, P., Byrne, C., Clancy, R.M., and Buyon, J.P. Antibody reactivity to α-enolase in mothers of children with congenital heart block. J. Rheumatol. 36:565-9.

Palafox-Sánchez, C.A., Satoh, M., Chan, E.K., Carcamo, W.C., Muñoz-Valle, J.F., Orozco-Barocio, G., Oregón-Romero, E., Navarro-Hernández, R.E., Salazar-Páramo, M., Castañeda, A.C., and Vázquez-Del Mercado, M. Reduced IgG anti-snRNPs autoantibody production in SLE patients with positive IgM anti-cytomegalovirus antibodies. Arthritis Res. Ther. 11:R27.

Nozawa, K., Ikeda, K., Satoh, M., Reeves, W.H., Stewart, C., Li, Y.C., Yen, T.J., Rios, R.M., Takamori, K., Ogawa, H., Sekigawa, I., Takasaki, Y., and Chan, E.K. Autoantibody to NA14 is an independent marker primarily for Sjögren’s Syndrome. Frontiers Biosci. 14:3733-3739.

Bulosan, M., Pauley, K.M., Yo, K., Chan, E.K., Katz, J., Peck, A.B., and Cha, S. Inflammatory caspases are critical for enhanced cell death in the target tissue of Sjögren’s Syndrome prior to disease onset. Immunol. Cell Biol. 87:81-90.

Nozawa, K., Fritzler, M.J., Takasaki, Y., Wood, M.R., and Chan, E.K. Co-clustering of Golgi complex and other cytoplasmic organelles to crescentic region of half-moon nuclei during apoptosis. Cell Biol. Int. 33:148-157.

2008

Li, S., Lian, S.L., Moser, J.J., Fritzler, M.L., Fritzler, M.J., Satoh, M., and Chan, E.K. Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2 mediated silencing. J. Cell Sci. 121:4134-44.

Pauley, K.M., Satoh, M., Chan, A.L., Bubb, M.R., Reeves, W.H., and Chan, E.K. Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arth. Res. Ther. 10:R101.

Nozawa, K., Fritzler, M.J., Ikeda, K., Takasaki, Y., Satoh, M., and Chan, E.K. Differential anti-Golgi complex autoantibody production in murine lactate dehydrogenase-elevating virus infection. Immunopharmacology and Immunotoxicology 30:13-25.

Kakumanu, P., Yamagata, H., Sobel, E.S., Reeves, W.H., Chan, E.K., and Satoh, M. Patients with pulmonary tuberculosis are frequently positive for anti-CCP antibodies but they also react with unmodified arginine peptide. Arthritis Rheum. 58:1576-81.

2007

Lian, S., Fritzler, M.J., Katz, J., Hamazaki, T., Terada, N., Satoh, M., and Chan, E.K. Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies. Mol. Biol. Cell 18:3375-87. Expert Reviews written by Herrera-Esparza et al, 2008

Jakymiw, A., Pauley, K.M., Li, S., Lian, S., Ikeda, K., Eystathioy, T., Satoh, M., Fritzler, M.J., and Chan, E.K. The role of GW/P-bodies in RNA processing and silencing. J. Cell Sci., 120:1317-23.

Zhang, J.Y., Megliorino, R., Peng, X.X., Tan, E.M., Chen, Y., and Chan, E.K. Antibody detection using tumor-associated antigen mini-array in immunodiagnosing human hepatocellular carcinoma. J. Hepatol. 46:107-114.

Chan, E.K., Fritzler, M.J., Wiik, A., Andrade, L.E.C., Reeves, W.H., Tincani, A., Meroni, P.L., and the IUIS/WHO/AF/CDC committee for the standardization of autoantibodies in rheumatic and related diseases. AutoAbSC.Org – Autoantibody Standardization Committee in 2006. Autoimmunity Rev. 6:577-80.

Bhanji, R.A., Eystathioy, T., Chan, E.K., Bloch, D.B., and Fritzler, M.J. Clinical and serological features of patients with autoantibodies to GW/P Bodies. Clin. Immunol. 125:247-56.

Yamasaki, Y., Narain, S., Yoshida, H., Hernandez, L., Barker, T., Hahn, P.C., Sobel, E.S., Segal, M.S., Richards, H.B., Chan, E.K., Reeves, W.H., and Satoh, M. Autoantibodies to RNA helicase A: A new serological marker of early lupus. Arthritis Rheum. 56:596-604.

Moser, J.J., Eystathioy, T., Chan, E.K., and Fritzler, M.J. Markers of mRNA stabilization, degradation and RNAi within astrocytoma GW bodies. J. Neuroscience Research, 85:3619-3631.

2006

Ikeda, K., Satoh, M., Pauley, K.M., Fritzler, M.J., Reeves, W.H., and Chan, E.K. Detection of the argonaute protein Ago2 and microRNAs in the RNA induced silencing complex (RISC) using a monoclonal antibody. J. Immunol. Methods 317:38-44.

Pauley, K.M., Eystathioy, T., Jakymiw, A., Hamel J.C., Fritzler, M.J., and Chan, E.K. Formation of GW bodies is a consequence of miRNA genesis. EMBO Reports 7:904-910.

Jakymiw, A., Ikeda, K., Fritzler, M.J., Reeves, W.H., Satoh, M., and Chan, E.K. Autoimmune targeting of key components of RNA interference. Arthritis Res. Ther., 8:R87.

Lian, S., Jakymiw, A., Eystathioy, T., Hamel, J.C., Fritzler, M.J., and Chan, E.K. GW bodies, microRNAs and the cell cycle. Cell Cycle 5:242-5.

Yamasaki, Y., Yamada, H., Nozaki, T., Akaogi, J., Nichols, C., Lyons, R., Loy, A.C., Chan, E.K., Reeves, W.H., and Satoh, M. Unusually high frequency of autoantibodies to PL-7 associated with milder muscle disease in Japanese patients with polymyositis/dermatomyositis. Arthritis Rheum. 54:2004-9.

Yamasaki, Y., Narain, S., Hernandez, L., Barker, T., Ikeda, K., Segal, M.S., Richards, H.B., Chan, E.K., Reeves, W.H., and Satoh, M. Autoantibodies against the replication protein A complex in SLE and other autoimmune diseases. Arthritis Res. Ther. 8:R111.

Yamasaki, Y., Narain, S., Ikeda, K., Honkannen-Scott, M., Hernandez, B.S., Barker, T., Richards, H.B., Chan, E.K., Reeves, W.H., and Satoh, M. Nucleolar staining cannot be used as a screening test for the scleroderma marker anti-RNA polymerase I/III antibodies. Arthritis Rheum. 54:3051-6.

2005

Jakymiw, A., Lian, S., Eystathioy, T., Li, S., Satoh, M., Hamel J.C., Fritzler, M.J., and Chan, E.K. Disruption of GW bodies impairs mammalian RNA Interference. Nature Cell Biol. 7:1267-74.

Lu, Y., Ye, P., Chen, S-L., Tan, E.M., and Chan, E.K. Identification of kinectin as a novel Behçet’s disease autoantigen. Arthritis Res. Ther. 7:R1133-9.

Clancy, R.M., Buyon, J.P., Ikeda, K., Nozawa, K., Argyle, D.A., Friedman, D.M., and Chan, E.K. Maternal antibody responses to the 52kD SS-A/Ro p200 peptide and the development of fetal conduction defects. Arthritis Rheum. 52:3079-86.

2004

Nozawa, K., Fritzler, M.J., von Mühlen, C.A., and Chan, E.K. Giantin is the major Golgi autoantigen in human anti-Golgi complex sera. Arthritis Res. Ther. 6:R95-R102.

Yang, Z., Jakymiw, A., Wood, M.R., Eystathioy, T., Rubin, R.L., Fritzler, M.J., and Chan, E.K. GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation. J. Cell Science 117:5567-78.

2003

Eystathioy, T., Chan, E.K., Mahler, M., Luft, L.M., Fritzler, M.L., and Fritzler, M.J. A panel of monoclonal antibodies to cytoplasmic GW bodies and the mRNA binding protein GW182. Hybridoma & Hybridomics, 22:79-86.

Eystathioy, T., Jakymiw, A., Chan, E.K., Séraphin, B., Cougot, N., and Fritzler, M.J. The GW182 protein co-localizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies. RNA 9:1171-1173.

Eystathioy, T., Chan, E.K., Takeuchi, K., Mahler, M., Luft, L.M., Zochodne, D.W., and Fritzler, M.J. Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182. J. Mol. Med., 81:811-818.

2002

Eystathioy, T., Chan, E.K., Tenenbaum, S.A., Keene, J.D., Griffith, K., and Fritzler, M.J. A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles. Mol. Biol. Cell 13: 1338-51.

Selected Chapters, Reviews & Editorials

2014

Calise, S.J., Carcamo, W.C., Ceribelli, A., Dominguez, Y., Satoh, M., and Chan, E.K. Antibodies to rods and rings. In Autoantibodies (Shoenfeld, Y., Meroni, P.L., Gershwin, M.E., Eds.), pp. 161-168. Elsevier Science, Third Edition.

Carcamo, W.C., Calise, S.J., von Mühlen, C.A., Satoh, M., and Chan, E.K. Molecular cell biology and immunobiology of mammalian rod/ring structures. Int Rev Cell Mol Biol., 308:35-74.

2013

Chan, E.K., Ceribelli, A., and Satoh, M. MicroRNA-146a in autoimmunity and innate immune responses. Ann Rheum Dis. 72:ii90-ii95.

Chan, E.K., Yao, B., and Fritzler, M.J. Reflections on ten years of history of, and future prospects for, GW182 and GW/P body research. In Ten Years of Progress in GW/P Body Research, edited by E.K.L. Chan and M.J. Fritzler, Adv Exp Med Biol, 768:261-70.

Chan, E.K. and Fritzler, M.J. Introduction – The GW body story as an example of autoantibodies with significant impacts to molecular cell biology. In Ten Years of Progress in GW/P Body Research, edited by E.K.L. Chan and M.J. Fritzler, Adv Exp Med Biol, 768:1-4.

Fritzler, M.J. and Chan, E.K. The discovery of GW bodies. In Ten Years of Progress in GW/P Body Research, edited by E.K.L. Chan and M.J. Fritzler, Adv Exp Med Biol, 768:5-21.

Satoh, M., Chan, J.Y., Ceribelli, A., Vazquez del-Mercado, M., and Chan, E.K. Autoantibodies to Argonaute 2 (Su antigen). In Ten Years of Progress in GW/P Body Research, edited by E.K.L. Chan and M.J. Fritzler, Adv Exp Med Biol, 768:45-59.

Yao, B., Li, S., and Chan, E.K. Function of GW182 and GW bodies in siRNA and miRNA pathways. In Ten Years of Progress in GW/P Body Research, edited by E.K.L. Chan and M.J. Fritzler, Adv Exp Med Biol, 768:71-96.

Moser, J.J., Chan, E.K., and Fritzler, M.J. An SNP in the trinucleotide repeat region of the GW182/TNRC6A gene maps to a major TNGW1 autoepitope in patients with autoantibodies to GW182. In Ten Years of Progress in GW/P Body Research, edited by E.K.L. Chan and M.J. Fritzler, Adv Exp Med Biol, 768:243-59.

2012

Satoh, M., Ceribelli, A., and Chan, E.K. Common pathways of autoimmune inflammatory myopathies and genetic neuromuscular disorders. Clin. Rev. Allergy Immunol. 42:16-25.

2011

Chan, E.K., Ceribelli, A., and Nahid, M.A. The role of miRNAs in the regulation of immunological functions and the prevention of autoimmunity. In: K. Conrad, E.K.L. Chan, M.J. Fritzler, R.L. Humbel, P.L. Meroni, Y. Shoenfeld (eds), From Prediction to Prevention of Autoimmune Diseases. Autoantigens, Autoantibodies and Autoimmunity series. Volume 7. Proceedings 10th Dresden Symposium on Autoantibodies. Pabst Science Publishers, Lengerich, Germany, pp253-266.

Ceribelli, A., Nahid, M.A., Satoh, M., and Chan, E.K. MicroRNAs in rheumatoid arthritis. FEBS Letters 585, pp. 3667-3674.

Ceribelli, A., Yao, B., Dominguez-Gutierrez, P.R., and Chan, E.K. Editorial: Lupus T cells switched on by DNA hypomethylation via microRNAs? Arthritis Rheum. 63:1177-81.

Ceribelli, A., Yao, B., Dominguez-Gutierrez, P.R., Nahid, M.A., Satoh, M., and Chan, E.K. MicroRNAs in systemic rheumatic diseases. Arthritis Res. Ther. 13:229.

Nahid, M.A., Satoh, M., and Chan, E.K. MicroRNA in TLR signaling and endotoxin tolerance. Cell. Mol. Immunol. 8:388-403.

2010

Chan, E.K. Autoantibodies to multiple components of the microRNA pathway and aberrant microRNA expression in autoimmune diseases. In: Jack D. Keene (ed), Autoantibodies and Autoimmunity, MBL, Tokyo, Japan, pp45-59.

Satoh, M., Fritzler, M.J., and Chan, E.K. Anti-histone and anti-spliceosomal antibodies. In Systemic Lupus Erythematosus, 5th ed. edited by Robert G. Lahita. Academic Press, San Diego, Chapter 16, pp. 275- 292.

2009

Katz, J. and Chan, E.K. Commentary: Cell cycle proteins to monitor cancer of salivary glands. Cancer Biol. Ther. 8:159-160.

Satoh, M., Vázquez-Del Mercado, M., and Chan, E.K. Clinical interpretation of antinuclear antibody tests in systemic rheumatic diseases. Mod. Rheum. 19:219-28.

Chan, E.K., Satoh, M., and Pauley, K.M. Editorial: Contrast in aberrant microRNA expression in SLE and RA: Is miR-146 all we need? Arthritis Rheum. 60:912-915.

Pauley, K.M., Cha, S., and Chan, E.K. MicroRNA in autoimmunity and autoimmune diseases. J. Autoimmunity 32:189-194.

2008

Pauley, K.M., and Chan, E.K. MicroRNAs and their emerging roles in immunology. In: Noel R. Rose (ed), The Year in Immunology, Ann. N.Y. Acad. Sci. 1143:226-39.

2007

Jakymiw, A., Pauley, K.M., Li, S., Lian, S., Ikeda, K., Eystathioy, T., Satoh, M., Fritzler, M.J., and Chan, E.K. The role of GW/P-bodies in RNA processing and silencing. J. Cell Sci., 120:1317-1323.

Satoh, M., Chan, E.K., Sobel, E.S., Kimpel, D.L., Yamasaki, Y., Narain, S., Mansoor, R., and Reeves, W.H. Clinical implication of autoantibodies in patients with systemic rheumatic diseases. Expert Rev. Clin. Immunol. 3:721-38.