Original Research Articles
(Chapters, Reviews, & Editorials and Books are listed below original research articles.)
2024
Chan EKL, Pollard KM, Fritzler MJ. Eng Meng Tan. Ann Rheum Dis. 2024 Jun 3;. doi: 10.1136/ard-2024-226025. [Epub ahead of print] PubMed PMID: 38830750.
Tan PK, Chan EKL, Fritzler MJ. Dr. Eng Meng Tan August 26, 1926 – March 9, 2024 La Jolla, California. Lupus. 2024 May 21:9612033241252038. doi: 10.1177/09612033241252038. Online ahead of print. PMID: 38770549
2023
Aravindraja C, Jeepipalli S, Duncan W, Vekariya KM, Bahadekar S, Chan EKL, Kesavalu L. Unique miRomics Expression Profiles in Tannerella forsythia-Infected Mandibles during Periodontitis Using Machine Learning. Int J Mol Sci. 2023 Nov 16;24(22):16393. doi: 10.3390/ijms242216393. PMID: 38003583
Aravindraja C, Jeepipalli S, Vekariya KM, Botello-Escalante R, Chan EKL, Kesavalu L. Oral Spirochete Treponema denticola Intraoral Infection Reveals Unique miR-133a, miR-486, miR-126-3p, miR-126-5p miRNA Expression Kinetics during Periodontitis. Int J Mol Sci. 2023 Jul 28;24(15). doi: 10.3390/ijms241512105. PMID: 37569480
Andrade LEC, Chan EKL, Vieths S, Engel P, Kirschfink M. Editorial: Contemporary challenges in immunologic testing in clinical and research laboratories. Front Immunol. 2023;14:1259823. doi: 10.3389/fimmu.2023.1259823. eCollection 2023. PubMed PMID: 37575258
Dinse GE, Zheng B, Co CA, Parks CG, Weinberg CR, Miller FW, Chan EKL. Anti-dense fine speckled 70 (DFS70) autoantibodies: correlates and increasing prevalence in the United States. Front Immunol. 2023;14:1186439. doi: 10.3389/fimmu.2023.1186439. eCollection 2023. PubMed PMID: 37426660.
Aravindraja C, Vekariya KM, Botello-Escalante R, Rahaman SO, Chan EKL, Kesavalu L. Specific microRNA Signature Kinetics in Porphyromonas gingivalis-Induced Periodontitis. Int J Mol Sci. 2023 Jan 24;24(3). doi: 10.3390/ijms24032327. PubMed PMID: 36768651.
Bonroy C, Vercammen M, Fierz W, Andrade LEC, Van Hoovels L, Infantino M, Fritzler MJ, Bogdanos D, Kozmar A, Nespola B, Broeders S, Patel D, Herold M, Zheng B, Chan EYT, Uibo R, Haapala AM, Musset L, Sack U, Nagy G, Sundic T, Fischer K, Rego de Sousa MJ, Vargas ML, Eriksson C, Heijnen I, García-De La Torre I, Carballo OG, Satoh M, Kim KH, Chan EKL, Damoiseaux J, Lopez-Hoyos M, Bossuyt X. Detection of antinuclear antibodies: recommendations from EFLM, EASI and ICAP. Clin Chem Lab Med. 2023 Jun 27;61(7):1167-1198. doi: 10.1515/cclm-2023-0209. Print 2023 Jun 27. PubMed PMID: 36989417.
Vercammen M, Bonroy C, Broeders S, Chan EKL, Bizzaro N, Bogdanos DP, Andrade L, Coucke W, de Melo Cruvinel W, Kozmar A, Kuhi L, Lutteri L, Rego de Sousa MJ, Schouwers S, Van Hoovels L, Bossuyt X. Analytical aspects of the antinuclear antibody test by HEp-2 indirect immunofluorescence: EFLM report on an international survey. Clin Chem Lab Med. 2023 Jun 27;61(7):1199-1208. doi: 10.1515/cclm-2023-0210. Print 2023 Jun 27. PubMed PMID: 36989428.
2022
Chan EKL. Anti-Ro52 Autoantibody Is Common in Systemic Autoimmune Rheumatic Diseases and Correlating with Worse Outcome when Associated with interstitial lung disease in Systemic Sclerosis and Autoimmune Myositis. Clin Rev Allergy Immunol. 2022 Oct;63(2):178-193. doi: 10.1007/s12016-021-08911-z. Epub 2022 Jan 18. Review
Dinse GE, Parks CG, Weinberg CR, Co CA, Wilkerson J, Zeldin DC, Chan EKL, Miller FW. Increasing Prevalence of Antinuclear Antibodies in the United States. Arthritis Rheumatol. 2022 Dec;74(12):2032-2041. doi: 10.1002/art.42330. Epub 2022 Oct 19. PubMed PMID: 36054084.
Chan EKL, von Mühlen CA, Fritzler MJ, Damoiseaux J, Infantino M, Klotz W, Satoh M, Musset L, García-De La Torre I, Carballo OG, Herold M, de Melo Cruvinel W, Mimori T, Andrade LEC. The International Consensus on ANA Patterns (ICAP) in 2021-The 6th Workshop and Current Perspectives. J Appl Lab Med. 2022 Jan 5;7(1):322-330. doi: 10.1093/jalm/jfab140.
Dinse, G.E., Co, C.A., Parks, C.G., Weinberg, C.R., Xie, G., Chan, E.K.L., Birnbaum, L.S., and Miller, F.W. Expanded Assessment of Xenobiotic Associations with Antinuclear Antibodies in the United States: 1988-2012. Environ. Int. 2022 166:107376.
Michikawa C, Gopalakrishnan V, Harrandah AM, Karpinets TV, Garg RR, Chu RA, Park YP, Chukkapallia SS, Yadlapalli N, Erikson-Carter KC, Gleber-Netto FO, Sayour E, Progulske-Fox A, Chan EKL, Wu X, Zhang J, Jobin C, Wargo JA, Pickering CR, Myers JN, Silver N. Fusobacterium is enriched in oral cancer and promotes induction of programmed death-ligand 1 (PD-L1). Neoplasia. 2022 Sep;31:100813. doi: 10.1016/j.neo.2022.100813. Epub 2022 Jul 11. PubMed PMID: 35834946.
Aravindraja C, Kashef MR, Vekariya KM, Ghanta RK, Karanth S, Chan EKL, Kesavalu L. Global Noncoding microRNA Profiling in Mice Infected with Partial Human Mouth Microbes (PAHMM) Using an Ecological Time-Sequential Polybacterial Periodontal Infection (ETSPPI) Model Reveals Sex-Specific Differential microRNA Expression. Int J Mol Sci. 2022 May 4;23(9). doi: 10.3390/ijms23095107. PubMed PMID: 35563501.
2021
Röber N, Dellavance A, Ingénito F, Reimer ML, Carballo OG, Conrad K, Chan EKL, Andrade LEC. Strong Association of the Myriad Discrete Speckled Nuclear Pattern With Anti-SS-A/Ro60 Antibodies: Consensus Experience of Four International Expert Centers. Front Immunol. 2021 Oct 5;12:730102. doi: 10.3389/fimmu.2021.730102. PMID: 34675922
von Mühlen CA, Garcia-De La Torre I, Infantino M, Damoiseaux J, Andrade LEC, Carballo OG, Conrad K, Francescantonio PLC, Fritzler MJ, Herold M, Klotz W, de Melo Cruvinel W, Mimori T, Satoh M, Musset L, Chan EKL. How to report the antinuclear antibodies (anti-cell antibodies) test on HEp-2 cells: guidelines from the ICAP initiative. Immunol Res. 2021 Dec;69(6):594-608. doi: 10.1007/s12026-021-09233-0. PMID: 34625914
Lehenaff R, Tamashiro R, Nascimento MM, Lee K, Jenkins R, Whitlock J, Li EC, Sidhu G, Anderson S, Progulske-Fox A, Bubb MR, Chan EKL, Wang GP. Subgingival microbiome of deep and shallow periodontal sites in patients with rheumatoid arthritis: a pilot study. BMC Oral Health. 2021 May 8;21(1):248. doi: 10.1186/s12903-021-01597-x. PMID: 33964928
Tebo AE, Schmidt RL, Kadkhoda K, Peterson LK, Chan EKL, Fritzler MJ, Wener MH. The antinuclear antibody HEp-2 indirect immunofluorescence assay: a survey of laboratory performance, pattern recognition and interpretation. Auto Immun Highlights. 2021 Feb 27;12(1):4. doi: 10.1186/s13317-020-00146-w. PMID: 33640027
2020
Harrandah AM, Chukkapalli SS, Bhattacharyya I, Progulske-Fox A, Chan EKL. Fusobacteria modulate oral carcinogenesis and promote cancer progression. J Oral Microbiol. 2020 Nov 30;13(1):1849493. doi: 10.1080/20002297.2020.1849493. PMID: 33391626
Van Hoovels L, Broeders S, Chan EKL, Andrade L, de Melo Cruvinel W, Damoiseaux J, Viander M, Herold M, Coucke W, Heijnen I, Bogdanos D, Calvo-Alén J, Eriksson C, Kozmar A, Kuhi L, Bonroy C, Lauwerys B, Schouwers S, Lutteri L, Vercammen M, Mayer M, Patel D, Egner W, Puolakka K, Tesija-Kuna A, Shoenfeld Y, de Sousa MJR, Hoyos ML, Radice A, Bossuyt X. Current laboratory and clinical practices in reporting and interpreting anti-nuclear antibody indirect immunofluorescence (ANA IIF) patterns: results of an international survey. Auto Immun Highlights. 2020 Nov 23;11(1):17. doi: 10.1186/s13317-020-00139-9. PMID: 33228811
Zheng B, Wang Z, Mora RA, Liu A, Li C, Liu D, Zhai F, Liu H, Gong H, Zhou J, Liu J, Chen L, Wu L, Yuan L, Ying L, Jie L, He M, Hao M, Xu P, Lu Q, Han S, Chen S, Chen S, Zhu S, Sun W, Guo X, Chen Y, Wang Y, Qu Y, Li Z, Niu Z, Han Z, Chan EKL. Anti-DFS70 Antibodies Among Patient and Healthy Population Cohorts in China: Results From a Multicenter Training Program Showing Spontaneous Abortion and Pediatric Systemic Autoimmune Rheumatic Diseases Are Common in Anti-DFS70 Positive Patients. Front Immunol. 2020;11:562138. doi: 10.3389/fimmu.2020.562138. PMID: 33133072
Zheng B, Mora RA, Fritzler MJ, Satoh M, Bloch DB, Garcia-De La Torre I, Boylan K, Kohl K, Wener MH, Andrade LEC, Chan EKL. Establishment of international autoantibody reference standards for the detection of autoantibodies directed against PML bodies, GW bodies, and NuMA protein. Clin Chem Lab Med. 2020 Aug 10:/j/cclm.ahead-of-print/cclm-2020-0981/cclm-2020-0981.xml. doi: 10.1515/cclm-2020-0981. PMID: 32776893
Andrade LEC, Damoiseaux J, Chan EK. Response to ‘Decision making value of nuclear dense fine speckled pattern in systemic autoimmune rheumatic disease: trick or treat?’ by Deng et al. Ann Rheum Dis. 2020 Aug;79(8):e93. doi: 10.1136/annrheumdis-2019-215640. Epub 2019 May 15.PMID: 31092413
Dinse GE, Parks CG, Weinberg CR, Co CA, Wilkerson J, Zeldin DC, Chan EKL, Miller FW. Increasing Prevalence of Antinuclear Antibodies in the United States. Arthritis Rheumatol. 2020 Jun;72(6):1026-1035. doi: 10.1002/art.41214. PMID: 32266792
Damoiseaux J, Chan EK. Response to: ‘The utility of the HEp-2000 antinuclear antibody substrate’ by Lee et al. Ann Rheum Dis. 2020 Jun;79(6):e68. doi: 10.1136/annrheumdis-2019-215610. Epub 2019 May 14.PMID: 31088789
2019
Dellavance A, Baldo DC, Zheng B, Mora RA, Fritzler MJ, Hiepe F, Rönnelid J, Satoh M, Garcia de la Torre I, Wener MH, Chan EKL, and Andrade LEC. Establishment of an international autoantibody reference standard for human anti-DFS70 antibodies: proof-of-concept study for a novel Megapool strategy by pooling individual specific sera. Clin Chem Lab Med. 2019 Oct 25;57(11):1754-1763. doi: 10.1515/cclm-2019-0087.
Damoiseaux J, Andrade LEC, Carballo OG, Conrad K, Francescantonio PLC, Fritzler MJ, Garcia de la Torre I, Herold M, Klotz W, Cruvinel WM, Mimori T, von Muhlen C, Satoh M, Chan EK. Clinical relevance of HEp-2 indirect immunofluorescent patterns: the International Consensus on ANA patterns (ICAP) perspective. Ann Rheum Dis. 2019 Jul;78(7):879-889. doi: 10.1136/annrheumdis-2018-214436. PMID: 30862649
Keppeke GD, Calise SJ, Chan EKL, and Andrade LEC. Ribavirin induces widespread accumulation of IMP dehydrogenase into rods/rings structures in multiple major mouse organs. Antiviral Res. 162:130-135.
2018
Calise SJ, Abboud G, Kasahara H, Morel L, and Chan EKL. Immune response-dependent assembly of IMP dehydrogenase filaments. Front Immunol. 9:2789.
Vracar TC, Zuo J, Park J, Azer D, Mikhael C, Holliday SA, Holsey D, Han G, VonMoss L, Neubert JK, Rody WJ Jr, Chan EKL, and Holliday LS. Enoxacin and bis-enoxacin stimulate 4T1 murine breast cancer cells to release extracellular vesicles that inhibit osteoclastogenesis. Sci Rep. 8:16182.
Ding S, Das SR, Brownlee BJ, Parate K, Davis TM, Stromberg LR, Chan EKL, Katz J, Iverson BD, and Claussen JC. CIP2A immunosensor comprised of vertically-aligned carbon nanotube interdigitated electrodes towards point-of-care oral cancer screening. Biosens Bioelectron. 117:68-74.
Herold M, Klotz W, Andrade LEC, Conrad K, Cruvinel WM, Damoiseaux J, Fritzler MJ, von Mühlen CA, Satoh M, and Chan EKL. International Consensus on Antinuclear Antibody Patterns: defining negative results and reporting unidentified patterns. Clin Chem Lab Med. 56(10):1799-1802.
Calise SJ, Zheng B, Hasegawa T, Satoh M, Isailovic N, Ceribelli A, Andrade LEC, Boylan K, Cavazzana I, Fritzler MJ, Garcia de la Torre I, Hiepe F, Kohl K, Selmi C, Shoenfeld Y, Tincani A, and Chan EKL. Reference standards for the detection of anti-mitochondrial and anti-rods/rings autoantibodies. Clin Chem Lab Med. 56(10):1789-1798.
Andrade LEC, Klotz W, Herold M, Conrad K, Rönnelid J, Fritzler MJ, von Mühlen CA, Satoh M, Damoiseaux J, Cruvinel WM, and Chan EKL; the Executive Committee of ICAP. International consensus on antinuclear antibody patterns: definition of the AC-29 pattern associated with antibodies to DNA topoisomerase I. Clin Chem Lab Med. 56(10):1783-1788.
Dinse GE, Parks CG, Meier HCS, Co CA, Chan EKL, Jusko TA, Yeh J, and Miller FW. Prescription medication use and antinuclear antibodies in the United States, 1999-2004. J Autoimmun. 92:93-103.
Park YP, Jin L, Bennett KB, Wang D, Fredenburg KM, Tseng JE, Chang LJ, Huang J, and Chan EKL. CD70 as a target for chimeric antigen receptor T cells in head and neck squamous cell carcinoma. Oral Oncol. 78:145-150.
2017
Dinse GE, Parks CG, Weinberg CR, Meier HCS, Co CA, Chan EKL, and Miller FW. Antinuclear antibodies and mortality in the National Health and Nutrition Examination Survey (1999-2004). PLoS One. 12(10):e0185977.
Venkatesh P, Phillippi J, Chukkapalli S, Rivera-Kweh M, Velsko I, Gleason T, Van Ryzin P, Aalaei-Andabili SH, Ghanta RK, Beaver T, Chan EKL, and Kesavalu L. Aneurysm-Specific miR-221 and miR-146a Participates in Human Thoracic and Abdominal Aortic Aneurysms. Int J Mol Sci. 18(4):E875.
2016
Calise, S.J., Bizzaro, N., Nguyen, T., Bassetti, D., Porcelli, B., Almi, P., Barberio, G., Pesce, G., Satoh, M., and Chan, E.K. Anti-rods/rings autoantibody seropositivity does not affect response to telaprevir treatment for chronic hepatitis C infection. Auto Immun Highlights. 7(1):15.
Uomori K, Nozawa K, Ikeda K, Doe K, Yamada Y, Yamaguchi A, Fujishiro M, Kawasaki M, Morimoto S, Takamori K, Sekigawa I, Chan EK, and Takasaki Y. A re-evaluation of anti-NA-14 antibodies in patients with primary Sjögren’s syndrome: Significant role of interferon-γ in the production of autoantibodies against NA-14. Autoimmunity 49(5):347-56.
Keppeke, G.D., Prado, M.S., Nunes E., Perazzio, S.F., Rodrigues, S.H., Ferraz M.L., Chan, E.K., and Andrade, L.E. Differential capacity of therapeutic drugs to induce rods/rings structures in vitro and in vivo and generation of anti-rods/rings autoantibodies. Clin Immunol. 173:149-156.
Harrandah, A.M., Fitzpatrick, S.G., Smith, M.H., Wang, D., Cohen, D.M., and Chan, E.K. MicroRNA-375 as a Biomarker for Malignant Transformation in Oral Lesions. Oral Surg Oral Med Oral Pathol Oral Radiol. 122(6):743-752.e1.
Calise, S.J., Purich, D.L., Nguyen, T., Saleem, D.A., Krueger, C., Yin, J.D., and Chan, E.K. ‘Rod and ring’ formation from IMP dehydrogenase is regulated through the one-carbon metabolic pathway. J Cell Sci. 129(15):3042-52.
Chukkapalli, S., Rivera-Kweh, M., Gehlot, P., Velsko, I., Bhattacharyya, I., Calise, S.J., Satoh, M., Chan, E.K., Holoshitz, J., and Kesavalu, L. Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice. Arthritis Res Ther. 18(1):161.
Esfandiary L, Gupta N, Voigt A, Wanchoo A, Chan EK, Sukumaran S, and Nguyen CQ. Single-cell antibody nanowells: a novel technology in detecting anti-SSA/Ro60- and anti-SSB/La autoantibody-producing cells in peripheral blood of rheumatic disease patients. Arthritis Res Ther. 18(1):107.
Dinse, G.E., Jusko, T.A., Whitt, I.Z., Co, C.A., Parks, C.G., Satoh, M., Chan, E.K., Rose, K.M., Walker, N.J., Birnbaum, L.S., Zeldin, D.C., Weinberg, C.R., and Miller, F.W. Associations between Selected Xenobiotics and Antinuclear Antibodies in the National Health and Nutrition Examination Survey, 1999-2004. Environ Health Perspect. 124(4):426-36.
Noble, J.W., Hunter, D.V., Roskelley, C.D., Chan, E.K., and Mills, J. Loukoumasomes are distinct subcellular structures from rods and rings and are structurally associated with MAP2 and the nuclear envelope in retinal cells. PLoS One. 11(10):e0165162.
2015
Nahid, M.A., Satoh, M., and Chan, E.K. Interleukin 1β-Responsive MicroRNA-146a Is Critical for the Cytokine-Induced Tolerance and Cross-Tolerance to Toll-Like Receptor Ligands. J Innate Immun. 7:428-40.
Keppeke, G.D., Calise, S.J., Chan, E.K., and Andrade, L.E. Assembly of IMPDH2-based, CTPS-based, and mixed rod/ring structures is dependent on cell type and conditions of induction. J Genet Genomics 42(6):287-299.
Keppeke, G.D., Andrade, L.E., Grieshaber, S.S., and Chan, E.K. Microinjection of specific anti-IMPDH2 antibodies induces disassembly of cytoplasmic rods/rings that are primarily stationary and stable structures. Cell Biosci. 5:1.
Jung, H.M., Benarroch, Y., and Chan, E.K. Anti-cancer drugs reactivate tumor suppressor miR-375 expression in tongue cancer cells. J Cell Biochem. 116:836-43.
Libório-Kimura, T.N., Jung, H.M., and Chan, E.K. miR-494 represses HOXA10 expression and inhibits cell proliferation in oral cancer. Oral Oncol. 51:151-7.
Peng, B., Lei, N., Chai, Y., Chan, E.K., and Zhang, J.Y. CIP2A regulates cancer metabolism and CREB phosphorylation in non-small cell lung cancer. Mol Biosyst. 11:105-14.
2014
Ceribelli, A., Fredi, M., Taraborelli, M., Cavazzana, I., Tincani, A., Selmi, C., Chan, J.Y., Chan, E.K., Satoh, M., and Franceschini, F. Prevalence and clinical significance of anti-MDA5 antibodies in European patients with polymyositis/dermatomyositis. Clin Exp Rheumatol. 32:891-7.
Parks, C.G., Miller, F.W., Satoh, M., Chan, E.K., Andrushchenko, Z., Birnbaum, L.S., Jusko, T.A., Kissling, G.E., Patel, M.D., Rose, K.M., Weinberg, C., Zeldin, D.C., and Sandler, D.P. Reproductive and hormonal risk factors for antinuclear antibodies (ANA) in a representative sample of U.S. women. Cancer Epidemiol Biomarkers Prev. 23:2492-502.
Mahler, M., Satoh, M., Hudson, M., Baron, M., Chan, J.Y., Chan, E.K., Wick, J., Fritzler, M.J., and the Canadian Scleroderma Research Group. Autoantibodies to the Rpp25 component of the Th/To complex are the most common antibodies in patients with systemic sclerosis without antibodies detectable by widely available commercial tests. J Rheumatol. 41:1334-43.
Jung, H.M., Phillips, B.L., and Chan, E.K. miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3ζ. Mol Cancer. 13:80.
Keppeke, G.D., Satoh, M., Ferraz, M.L., Chan, E.K., and Andrade, L.E. Temporal evolution of human autoantibody response to cytoplasmic rods and rings structure during anti-HCV therapy with ribavirin and interferon-α. Immunol Res. 60:38-49.
Dominguez-Gutierrez, P.R., Ceribelli, A., Satoh, M., Sobel, E.S., Reeves, W.H., and Chan, E.K. Reduced levels of CCL2 and CXCL10 in systemic lupus erythematosus patients under treatment with prednisone, mycophenolate mofetil, or hydroxychloroquine, except in a high STAT1 subset. Arthritis Res Ther. 16:R23.
Dominguez-Gutierrez, P.R., Ceribelli, A., Satoh, M., Sobel, E.S., Reeves, W.H., and Chan, E.K. Elevated signal transducers and activators of transcription 1 correlates with increased C-C motif chemokine ligand 2 and C-X-C motif chemokine 10 levels in peripheral blood of patients with systemic lupus erythematosus. Arthritis Res Ther. 16:R20.
Calise, S.J., Carcamo, W.C., Krueger, C., Yin, J.D., Purich, D.L., and Chan, E.K. Glutamine deprivation initiates reversible assembly of mammalian rods and rings. Cell Mol Life Sci. 71:2963-73.
Dominguez-Gutierrez, P.R., Ceribelli, A., Satoh, M., Sobel, E.S., Reeves, W.H., and Chan, E.K. Positive Correlation of STAT1 and miR-146a with Anemia in Patients with Systemic Lupus Erythematosus. J Clin Immunol. 34:171-80.
Agmon-Levin, N., Damoiseaux, J., Kallenberg, C., Sack, U., Witte, T., Herold, M., Bossuyt, X., Musset, L., Cervera, R., Plaza-Lopez, A., Dias, C., Sousa, M.J., Radice, A., Eriksson, C., Hultgren, O., Viander, M., Khamashta, M., Regenass, S., Andrade, L.E., Wiik, A., Tincani, A., Rönnelid, J., Bloch, D.B., Fritzler, M.J., Chan, E.K., Garcia De La Torre, I., Konstantinov, K.N., Lahita, R., Wilson, M., Vainio, O., Fabien, N., Sinico, R.A., Meroni, P., and Shoenfeld, Y. International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies. Ann Rheum Dis. 73:17-23.
2013
Meroni, P.L., Chan, E.K., Tincani, A., Garcia de la Torre, I., and Andrade, L.E. Antinuclear antibody test: when to order? Am J Med. 126:e17.
Mahler, M., Gascon, C., Patel, S., Ceribelli, A., Fritzler, M.J., Swart, A., Chan, E.K., and Satoh, M. Rpp25 is a major target of autoantibodies to the Th/To complex as measured by a novel chemiluminescent assay. Arthritis Res Ther. 15:R50.
Petri, M.H., Satoh, M., Martin-Marquez, B.T., Vargas-Ramírez, R., Jara, L.J., Saavedra, M.A., Cruz-Gonzalez, C., Andrade-Ortega, L., Vera-Lastra, O., Salazar-Páramo, M., Prieto-Parra, R.E., Gonzalez-Lopez, L., Gamez-Nava, J.I., Ramírez-Sánchez, H.U., Chan, J.Y., Ross, S.J., Chan, E.K., and Vázquez-Del Mercado, M. Implications in the difference of anti-Mi-2 and -p155/140 autoantibody prevalence in two dermatomyositis cohorts from Mexico City and Guadalajara. Arthritis Res Ther. 15:R48.
Jung, H.M., Patel, R.S., Phillips, B.L., Wang, H., Cohen, D.M., Reinhold, W.C., Chang, L.J., Yang, L.J., and Chan, E.K. Tumor suppressor miR-375 regulates MYC expression via repression of CIP2A coding sequence through multiple miRNA-mRNA interaction. Mol Biol Cell. 24:1638-48.
Nahid, M.A., Yao, B., Dominguez-Gutierrez, P.R., Kesavalu, L., Satoh, M., and Chan, E.K. Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212. J Immunol. 190:1250-63.
Carcamo, W.C., Ceribelli, A., Calise, S.J., Krueger, C., Liu, C., Daves, M., Villalta, D., Bizzaro, N., Satoh, M., and Chan, E.K. Differential reactivity to IMPDH2 by anti-rods/rings autoantibodies and unresponsiveness to pegylated interferon-alpha/ribavirin therapy in US and Italian HCV patients. J Clin Immunol. 33:420-6.
Laine, A., Sihto, H., Come, C., Rosenfeldt, M.T., Zwolinska, A., Niemelä, M., Khanna, A., Chan, E.K., Kähäri, V.M., Kellokumpu-Lehtinen, P.L., Sansom, O.J., Evan, G.I., Junttila, M.R., Ryan, K.M., Marine, J.C., Joensuu, H., and Westermarck, J. Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Cancer Discov. 3:182-97.
2012
Yao, B., La, L.B., Chen, Y.C., Chang, L.J., and Chan, E.K. Defining a new role of GW182 in maintaining miRNA stability. EMBO Rep. 13:1102-8.
Keppeke, G.D., Nunes, E., Ferraz, M.L., Silva, E.A., Granato, C., Chan, E.K., and Andrade, L.E. Longitudinal Study of a Human Drug-Induced Model of Autoantibody to Cytoplasmic Rods/Rings following HCV Therapy with Ribavirin and Interferon-α. PLoS One 7:e45392.
Jung, H.M., Phillips, B.L., Patel, R.S., Cohen, D.M., Jakymiw, A., Kong, W.W., Cheng, J.Q., and Chan, E.K. Keratinization-associated miR-7 and miR-21 regulate tumor suppressor reversion-inducing-cysteine-rich protein with kazal motifs (RECK) in oral cancer. J Biol Chem. 287:29261-72.
Ceribelli, A., Satoh, M., and Chan, E.K. A new immunoprecipitation-real time quantitative PCR assay for anti-Th/To and anti-U3RNP antibody detection in systemic sclerosis. Arthritis Res Ther. 14:R128.
Ceribelli, A., Fredi, M., Taraborelli, M., Cavazzana, I., Franceschini, F., Quinzanini, M., Tincani, A., Ross, S.J., Chan, J.Y., Pauley, B.A., Chan, E.K., and Satoh, M. Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis. Arthritis Res Ther. 14:R97.
Satoh, M., Chan, J.Y., Ross, S.J., Li, Y., Yamasaki, Y., Yamada, H., Vazquez-Del Mercado, M., Petri, M., Jara, L.J., Saavedra, M.A., Cruz-Reyes, C., Sobel, E.S., Reeves, W.H., Ceribelli, A., and Chan, E.K. Autoantibodies to transcription intermediary factor (TIF)1beta associated with dermatomyositis. Arthritis Res Ther. 14:R79.
Ventelä, S., Côme, C., Mäkelä, J.A., Hobbs, R.M., Mannermaa, L., Kallajoki, M., Chan, E.K., Pandolfi, P.P., Toppari, J., and Westermarck, J. CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice. PLoS One 7:e33209.
Satoh, M., Ceribelli, A., and Chan, E.K. Role of environmental factors in autoantibody production – importance of a detailed analysis in a small cohort. Arthritis Res Ther. 14:109.
Satoh, M., Chan, E.K., Ho, L.A., Rose, K.M., Parks, C.G., Cohn, R.D., Jusko, T.A., Walker, N.J., Germolec, D.R., Whitt, I.Z., Crockett, P.W., Pauley, B.A., Chan, J.Y., Ross, S.J., Birnbaum, L.S., Zeldin, D.C., and Miller, F.W. Prevalence and sociodemographic correlates of antinuclear antibodies in the United States. Arthritis Rheum. 64:2319-27.
Covini, G., Carcamo, W.C., Bredi, E., von Mühlen, C.A., Colombo, M., and Chan, E.K. Cytoplasmic rods and rings autoantibodies developed during pegylated interferon and ribavirin therapy in patients with chronic hepatitis C. Antivir Ther. 17:805-11.
2011
Carcamo, W.C., Satoh, M., Kasahara, H., Terada, N., Hamazaki, T., Chan, J.Y., Yao, B., Tamayo, S., Covini, G., von Mühlen, C.A., and Chan, E.K. Induction of cytoplasmic rods and rings structures by inhibition of the CTP and GTP synthetic pathway in mammalian cells. PLoS One 6:e29690.
Patel, R.S., Jakymiw, A., Yao, B., Pauley, B.A., Carcamo, W.C., Katz, J., Cheng, J.Q., and Chan, E.K. High resolution of microRNA signatures in human whole saliva. Arch. Oral Biol. 56:1506-13.
Satoh, M., Vázquez del Mercado, M., Krzyszczak, M.E., Li, Y., Ceribelli, A., Burlingame, R.W., Webb, T.T., Sobel, E.S., Reeves, W.H., and Chan, E.K. Coexistence of anti-RNA polymerase III and anti-U1RNP antibodies in patients with SLE – Two cases without features of scleroderma. Lupus 21:68-74.
Nahid, M.A., Satoh, M., and Chan, E.K. Mechanistic role of miR-146a in endotoxin-induced differential cross-regulation of TLR signaling. J Immunol. 186:1723-34.
Nahid, M.A., Rivera, M., Lucas, A., Chan, E.K., and Kesavalu, L. Polymicrobial infection with periodontal pathogens specifically enhances miR-146a in ApoE-/- mice during experimental periodontal disease. Infection Immun. 79:1597-605.
Satoh, M., Bjerkås, I., Haugarvoll, E., Chan, E.K., Szabo, N.J., Jirillo, E., Poppe, T.T., Sveier, H., Tørud, B., and Koppang, E.O. Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in farmed Atlantic salmon. Fish Shellfish Immunol. 30:1080-6.
Yao, B., Li, S., Lian, S.L., Fritzler, M.J., and Chan, E.K. Mapping of Ago2-GW182 functional interactions. Methods Mol. Biol. 725:45-62.
Satoh, M., Krzyszczak, M.E., Li, Y., Ceribelli, A., Ross, S.J., Chan, E.K., Segal, M.S., Bubb, M.R., Sobel, E.S., and Reeves, W.H. Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical study. Arthritis Res Ther. 13:R73.
Satoh, M., Chan, J.Y., Ross, S.J., Ceribelli, A., Cavazzana, I., Franceschini, F., Li, Y., Reeves, W.H., Sobel, E.S., and Chan, E.K. Autoantibodies to survival of motor neuron complex in patients with polymyositis: Immunoprecipitation of D, E, F, and G proteins without other components of small nuclear ribonucleoproteins. Arthritis Rheum. 63:1972-8.
Pauley, K.M., Stewart, C.M., Gauna A.E., Dupre, L.C., Kuklani, R., Chan, A.L., Pauley, B.A., Reeves, W.H., Chan, E.K., and Cha, S. Altered miR-146a expression in Sjögren’s syndrome and its functional role in innate immunity. European J. Immunol., 41:2029-39.
Ceribelli, A., Krzyszczak, M.E., Li, Y., Ross, S.J., Chan, J.Y.F., Chan, E.K., Burlingame, R., Webb, T.T., Bubb, M.R., Sobel, E.S., Reeves, W.H., and Satoh, M. Atypical clinical presentation of a subset of patients with anti-RNA polymerase III – non-scleroderma cases associated with dominant RNA polymerase I reactivity and nucleolar staining. Arthritis Res. Ther. 13:R119.
Pauley, K.M., Gauna A.E., Grichtchenko, I.I., Chan, E.K., and Cha, S. A secretagogue-small interfering RNA conjugate confers resistance to cytotoxicity in a cell model of Sjögren’s syndrome. Arthritis Rheum. 63:3116-25.
Krzyszczak, M.E., Li, Y., Ross, S.J., Ceribelli, A., Chan, E.K., Bubb, M.R., Sobel, E.S., Reeves, W.H., and Satoh, M. Gender and ethnicity differences in the prevalence of scleroderma-related autoantibodies. Clin. Rheumatol. 30:1333-9.
Yao, B., Li. S., Jung, H.M., Lian, S.L., Abadal, G.X., Han, F., Fritzler, M.J., and Chan, E.K. Divergent GW182 functional domains in the regulation of translational silencing. Nucleic Acids Res. 39:2534-47. PMC3074120.
Ceribelli, A., Tincani, A., Cavazzana, I., Franceschini, F., Cattaneo, R., Pauley, B.A., Chan, J.Y.F., Chan, E.K., and Satoh, M. Anti-argonaute2 (Ago2/Su) and -Ro antibodies identified by immunoprecipitation in primary anti-phospholipid syndrome (PAPS). Autoimmunity 44:90-7.
2010
Vázquez-Del Mercado, M., Sánchez Orozco, L.V., Pauley, B.A., Chan, J.Y.F., Chan, E.K., Panduro, A., Maldonado González, M., Jimenez-Luevanos, M.A., Martin Márquez, B.T., Palafox-Sanchez, C.A., Dávalos-Rodríguez, I.P., Salazar-Páramo, M., González Lopez, L., Gámez Nava, J.I., and Satoh, M. Autoantibodies to a miRNA-binding protein Argonaute 2 (Su antigen) in patients with hepatitis C virus infection. Clin. Exp. Rheumatol. 28:842-8.
Katz, J., Jakymiw, A., Ducksworth, M.K., Stewart, C.M., Bhattacharyya, I., Cha, S., and Chan, E.K. CIP2A expression and localization in oral carcinoma and dysplasia. Cancer Biology & Therapy. 10:694-699.
Ceribelli, A., Cavazzana, I., Franceschini, F., Airò, P., Tincani, A., Cattaneo, R., Pauley, B.A., Chan, E.K., and Satoh, M. Anti-Th/To are common anti-nucleolar autoantibodies in Italian scleroderma patients. J Rheumatol. 37:2071-5.
Jakymiw, A., Patel, R.S., Deming, N., Bhattacharyya, I., Shah, P., Lamont, R.J., Stewart, C., Cohen, D., and Chan, E.K. Overexpression of dicer as a result of reduced let-7 microRNA levels contributes to increased cell proliferation of oral cancer cells. Genes, Chromosomes and Cancer 49:540-59.
Pauley, K.M., Satoh, M., Pauley, B.A., Dominguez-Gutierrez, P.R., Wallet, S.M., Holliday, L.S., Cha, S., Reeves, W.H., and Chan, E.K. Formation of GW/P bodies as marker for microRNA-mediated regulation of innate immune signaling in THP-1 cells. Immunol. Cell Biol. 88:205-12.
Vázquez-Del Mercado, M., Palafox-Sánchez, C.A., Muñoz-Valle, J.F., Orozco-Barocio, G., Oregon Romero, E., Navarro Hernández, R.E., Salazar-Páramo, M., Chan, J.Y.F., Chan, E.K., and Satoh, M. High prevalence of autoantibodies to RNA helicase A in Mexican patients with systemic lupus erythematosus. Arthritis Res. Ther. 12:R6.
Pereira, D.B., Sannes, T., Dodd, S.M., Jensen, S.E., Morgan, L.S., and Chan, E.K. Life stress, negative mood states, and antibodies to heat shock protein 70 in endometrial cancer. Brain, Behavior, and Immunity 24:210-4.
2009
Ostrov, D.A., Magis, A.T., Wronski, T.J., Chan, E.K., Toro, E.J., Donatelli, R.E., Sajek, K., Haroun, I.N., Nagib, M.I. Piedrahita, A., Harris, A., and Holliday, L.S. Identification of enoxacin as an inhibitor of osteoclast formation and bone resorption by structure-based virtual screening. J. Med. Chem. 52:5144-5151.
Kakumanu, P., Sobel, E.S., Narain, S., Li, Y., Akaogi, J., Yamasaki, Y., Segal, M.S., Hahn, P.C., Chan, E.K., Reeves, W.H., and Satoh, M. Citrulline-dependence of anti-CCP antibodies in SLE as a marker of deforming/erosive arthritis. J. Rheumatol. 36:2682-90.
Nahid, M.A., Pauley, K.M., Satoh, M., and Chan, E.K. miR-146a is critical for endotoxin-induced tolerance: implication on innate immunity. J. Biol. Chem. 284:34590-34599.
Brucato, A., Grava, C., Bortolati, M., Ikeda, K., Milanesi, O., Cimaz, R., Ramoni, V., Vignati, G., Martinelli, S., Sadou, Y., Borghi, A., Tincani, A., Chan, E.K., and Ruffatti, A. Congenital Heart Block not associated with anti-Ro/La antibodies: comparison with anti-Ro/La-positive cases. J. Rheumatol. 36:1744-8.
Lian, S.L., Li. S., Abadal, G.X., Pauley, B.A., Fritzler, M.J., and Chan, E.K. The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing. RNA 15:804-13.
Moser, J.J., Chan, E.K., and Fritzler, M.J. Optimization of immunoprecipitation-western blot analysis in detecting GW182-associated components of GW/P Bodies. Nat Protoc. 4:674-85.
Llanos, C., Chan, E.K., Li, S., Abadal, G.X., Izmirly, P., Byrne, C., Clancy, R.M., and Buyon, J.P. Antibody reactivity to α-enolase in mothers of children with congenital heart block. J. Rheumatol. 36:565-9.
Palafox-Sánchez, C.A., Satoh, M., Chan, E.K., Carcamo, W.C., Muñoz-Valle, J.F., Orozco-Barocio, G., Oregón-Romero, E., Navarro-Hernández, R.E., Salazar-Páramo, M., Castañeda, A.C., and Vázquez-Del Mercado, M. Reduced IgG anti-snRNPs autoantibody production in SLE patients with positive IgM anti-cytomegalovirus antibodies. Arthritis Res. Ther. 11:R27.
Nozawa, K., Ikeda, K., Satoh, M., Reeves, W.H., Stewart, C., Li, Y.C., Yen, T.J., Rios, R.M., Takamori, K., Ogawa, H., Sekigawa, I., Takasaki, Y., and Chan, E.K. Autoantibody to NA14 is an independent marker primarily for Sjögren’s Syndrome. Frontiers Biosci. 14:3733-3739.
Bulosan, M., Pauley, K.M., Yo, K., Chan, E.K., Katz, J., Peck, A.B., and Cha, S. Inflammatory caspases are critical for enhanced cell death in the target tissue of Sjögren’s Syndrome prior to disease onset. Immunol. Cell Biol. 87:81-90.
Nozawa, K., Fritzler, M.J., Takasaki, Y., Wood, M.R., and Chan, E.K. Co-clustering of Golgi complex and other cytoplasmic organelles to crescentic region of half-moon nuclei during apoptosis. Cell Biol. Int. 33:148-157.
2008
Li, S., Lian, S.L., Moser, J.J., Fritzler, M.L., Fritzler, M.J., Satoh, M., and Chan, E.K. Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2 mediated silencing. J. Cell Sci. 121:4134-44.
Pauley, K.M., Satoh, M., Chan, A.L., Bubb, M.R., Reeves, W.H., and Chan, E.K. Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arth. Res. Ther. 10:R101.
Nozawa, K., Fritzler, M.J., Ikeda, K., Takasaki, Y., Satoh, M., and Chan, E.K. Differential anti-Golgi complex autoantibody production in murine lactate dehydrogenase-elevating virus infection. Immunopharmacology and Immunotoxicology 30:13-25.
Kakumanu, P., Yamagata, H., Sobel, E.S., Reeves, W.H., Chan, E.K., and Satoh, M. Patients with pulmonary tuberculosis are frequently positive for anti-CCP antibodies but they also react with unmodified arginine peptide. Arthritis Rheum. 58:1576-81.
Koppang, E.O., Bjerkås, I., Haugarvoll, E., Chan, E.K., Szabo, N.J., Ono, N., Akikusa, B., Jirillo, E., Poppe, T.T., Sveier, H., Tørud, B., and Satoh, M. Vaccination-induced systemic autoimmunity in farmed Atlantic salmon. J. Immunol. 181:4807-14.
2007
Lian, S., Fritzler, M.J., Katz, J., Hamazaki, T., Terada, N., Satoh, M., and Chan, E.K. Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies. Mol. Biol. Cell 18:3375-87. Expert Reviews written by Herrera-Esparza et al, 2008
Zhang, J.Y., Megliorino, R., Peng, X.X., Tan, E.M., Chen, Y., and Chan, E.K. Antibody detection using tumor-associated antigen mini-array in immunodiagnosing human hepatocellular carcinoma. J. Hepatol. 46:107-114.
Chan, E.K., Fritzler, M.J., Wiik, A., Andrade, L.E.C., Reeves, W.H., Tincani, A., Meroni, P.L., and the IUIS/WHO/AF/CDC committee for the standardization of autoantibodies in rheumatic and related diseases. AutoAbSC.Org – Autoantibody Standardization Committee in 2006. Autoimmunity Rev. 6:577-80.
Bhanji, R.A., Eystathioy, T., Chan, E.K., Bloch, D.B., and Fritzler, M.J. Clinical and serological features of patients with autoantibodies to GW/P Bodies. Clin. Immunol. 125:247-56.
Yamasaki, Y., Narain, S., Yoshida, H., Hernandez, L., Barker, T., Hahn, P.C., Sobel, E.S., Segal, M.S., Richards, H.B., Chan, E.K., Reeves, W.H., and Satoh, M. Autoantibodies to RNA helicase A: A new serological marker of early lupus. Arthritis Rheum. 56:596-604.
Moser, J.J., Eystathioy, T., Chan, E.K., and Fritzler, M.J. Markers of mRNA stabilization, degradation and RNAi within astrocytoma GW bodies. J. Neuroscience Research 85:3619-3631.
2006
Ikeda, K., Satoh, M., Pauley, K.M., Fritzler, M.J., Reeves, W.H., and Chan, E.K. Detection of the argonaute protein Ago2 and microRNAs in the RNA induced silencing complex (RISC) using a monoclonal antibody. J. Immunol. Methods 317:38-44.
Pauley, K.M., Eystathioy, T., Jakymiw, A., Hamel J.C., Fritzler, M.J., and Chan, E.K. Formation of GW bodies is a consequence of miRNA genesis. EMBO Reports 7:904-910.
Jakymiw, A., Ikeda, K., Fritzler, M.J., Reeves, W.H., Satoh, M., and Chan, E.K. Autoimmune targeting of key components of RNA interference. Arthritis Res. Ther. 8:R87.
Lian, S., Jakymiw, A., Eystathioy, T., Hamel, J.C., Fritzler, M.J., and Chan, E.K. GW bodies, microRNAs and the cell cycle. Cell Cycle 5:242-5.
Yamasaki, Y., Yamada, H., Nozaki, T., Akaogi, J., Nichols, C., Lyons, R., Loy, A.C., Chan, E.K., Reeves, W.H., and Satoh, M. Unusually high frequency of autoantibodies to PL-7 associated with milder muscle disease in Japanese patients with polymyositis/dermatomyositis. Arthritis Rheum. 54:2004-9.
Yamasaki, Y., Narain, S., Hernandez, L., Barker, T., Ikeda, K., Segal, M.S., Richards, H.B., Chan, E.K., Reeves, W.H., and Satoh, M. Autoantibodies against the replication protein A complex in SLE and other autoimmune diseases. Arthritis Res. Ther. 8:R111.
Yamasaki, Y., Narain, S., Ikeda, K., Honkannen-Scott, M., Hernandez, B.S., Barker, T., Richards, H.B., Chan, E.K., Reeves, W.H., and Satoh, M. Nucleolar staining cannot be used as a screening test for the scleroderma marker anti-RNA polymerase I/III antibodies. Arthritis Rheum. 54:3051-6.
2005
Jakymiw, A., Lian, S., Eystathioy, T., Li, S., Satoh, M., Hamel J.C., Fritzler, M.J., and Chan, E.K. Disruption of GW bodies impairs mammalian RNA Interference. Nature Cell Biol. 7:1267-74.
Lu, Y., Ye, P., Chen, S-L., Tan, E.M., and Chan, E.K. Identification of kinectin as a novel Behçet’s disease autoantigen. Arthritis Res. Ther. 7:R1133-9.
Clancy, R.M., Buyon, J.P., Ikeda, K., Nozawa, K., Argyle, D.A., Friedman, D.M., and Chan, E.K. Maternal antibody responses to the 52kD SS-A/Ro p200 peptide and the development of fetal conduction defects. Arthritis Rheum. 52:3079-86.
2004
Nozawa, K., Fritzler, M.J., von Mühlen, C.A., and Chan, E.K. Giantin is the major Golgi autoantigen in human anti-Golgi complex sera. Arthritis Res. Ther. 6:R95-R102.
Yang, Z., Jakymiw, A., Wood, M.R., Eystathioy, T., Rubin, R.L., Fritzler, M.J., and Chan, E.K. GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation. J. Cell Science 117:5567-78.
2003
Eystathioy, T., Chan, E.K., Mahler, M., Luft, L.M., Fritzler, M.L., and Fritzler, M.J. A panel of monoclonal antibodies to cytoplasmic GW bodies and the mRNA binding protein GW182. Hybridoma & Hybridomics 22:79-86.
Eystathioy, T., Jakymiw, A., Chan, E.K., Séraphin, B., Cougot, N., and Fritzler, M.J. The GW182 protein co-localizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies. RNA 9:1171-1173.
Eystathioy, T., Chan, E.K., Takeuchi, K., Mahler, M., Luft, L.M., Zochodne, D.W., and Fritzler, M.J. Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182. J. Mol. Med., 81:811-818.
2002
Eystathioy, T., Chan, E.K., Tenenbaum, S.A., Keene, J.D., Griffith, K., and Fritzler, M.J. A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles. Mol. Biol. Cell 13: 1338-51.
Selected Chapters, Reviews & Editorials
2020
Calise SJ, Chan EKL. Anti-rods/rings autoantibody and IMPDH filaments: an update after fifteen years of discovery. Autoimmun Rev. 2020 Aug 15:102643. doi: 10.1016/j.autrev.2020.102643. PMID: 32805424
2018
Chan EKL. Importance of Autoantibody Standardization. In Perspectives in Autoimmunity (published by Grifols, Barcelona, Spain), 1:3-11.
Harrandah AM, Mora RA, and Chan EKL. Emerging microRNAs in cancer diagnosis, progression, and immune surveillance. Cancer Lett. 438:126-132.
Chan EKL and Andrade LEC. Clarification Needed Regarding Anti-Topoisomerase I as a Biomarker for Non-Small Cell Lung Cancer. Ann Thorac Surg. 106:935.
Meroni PL, Chan EKL, Damoiseaux J, Andrade LEC, Bossuyt X, Conrad K, Mariette X, Sheldon J, Rönnelid J, and Fritzler MJ. Unending story of the indirect immunofluorescence assay on HEp-2 cells: old problems and new solutions? Ann Rheum Dis. [Epub ahead of print].
2017
Calise SJ and Chan EK. Advances in the immunobiology of autoantigenic rods/rings structures. In Immunodeficiency, Infection and Autoimmune Diseases – Report on the 13th Dresden Symposium on Autoantibodies (Conrad K, Andrade LEC, Chan EKL, Fritzler MJ, Pruijn GJM, Shoenfeld Y, and Steiner G, Eds.), pp. 71-80. Pabst Science Publishers, Lengerich, Germany, 2017.
Chan EK, Toubi E, and Conrad K. Biomarkers and Pathogenic Mechanisms in Autoimmunity. Immunol Res. 65(1):296-298.
Satoh, M., Tanaka, S., Ceribelli, A., Calise, S.J., and Chan, E.K. A Comprehensive Overview on Myositis-Specific Antibodies: New and Old Biomarkers in Idiopathic Inflammatory Myopathy. Clin Rev Allergy Immunol. 52(1):1-19.
2016
Keppeke, G.D., Calise, S.J., Chan, E.K., and Andrade, L.E. Anti-rods/rings autoantibody generation in hepatitis C patients during interferon-α/ribavirin therapy. World J Gastroenterol. 22(6):1966-74.
Fritzler, M.J. and Chan, E.K. Dr. Eng M. Tan: a tribute to an enduring legacy in autoimmunity. Lupus. Aug 17. pii: 0961203316664598. [Epub ahead of print]
Chan, E.K., Burlingame, R.W., and Fritzler, M.J. Detection of autoantibodies by enzyme-linked immunosorbent assay and bead assays. In Manual of Molecular and Clinical Laboratory Immunology, 8th ed. edited by Detrick, B., Schmitz, J.L., Hamilton, R.G., American Society for Microbiology Press, Washington, D.C., Chapter 88, p859-67.
Satoh, M, Ceribelli, A., Hirakata, M., and Chan, E.K. Immunodiagnosis of autoimmune myopathies. In Manual of Molecular and Clinical Laboratory Immunology, 8th ed. edited by Detrick, B., Schmitz, J.L., Hamilton, R.G., American Society for Microbiology Press, Washington, D.C., Chapter 90, p878-87.
Damoiseaux, J., von Mühlen, C.A., Garcia-De La Torre, I., Carballo, O.G., de Melo Cruvinel, W., Francescantonio, P.L., Fritzler, M.J., Herold, M., Mimori, T., Satoh, M., Andrade, L.E., Chan, E.K., and Conrad, K. International Consensus on ANA Patterns (ICAP): the bumpy road towards a consensus on reporting ANA results. Auto Immun Highlights. 7(1):1.
Satoh, M., Fritzler, M.J., and Chan, E.K. Anti-histone and anti-spliceosome antibodies. In Systemic Lupus Erythematosus – A Manual, edited by Tsokos, G., Academic Press/Elsevier, Chapter 25, p213-21.
Conrad, K., Andrade, L.E., Chan, E.K., Mahler, M., Meroni, P,L., Pruijn, G.J., Steiner, G., and Shoenfeld, Y. From autoantibody research to standardized diagnostic assays in the management of human diseases – Report of the 12 Dresden Symposium on Autoantibodies. Lupus. 25(8):787-96.
Chan, E.K., Damoiseaux, J., de Melo Cruvinel, W., Carballo, O.G., Conrad, K., Francescantonio, P.L., Fritzler, M.J., Garcia de la Torre, I., Herold, M., Mimori, T., Satoh, M., von Mühlen, C.A., and Andrade, L.E. Report on the second International Consensus on ANA Pattern (ICAP) workshop in Dresden 2015. Lupus. 25(8):797-804.
von Mühlen, C.A., Fritzler, M.J., and Chan, E.K. Clinical and laboratory evaluation of systemic rheumatic diseases. In Henry’s Clinical Diagnosis and Management by Laboratory Methods, edited by Richard McPherson and Matthew Pincus, 23rd edition. Chapter 52. Elsevier, p993-1015.
2015
Chan, E.K., de Melo Cruvinel, W., and Andrade, L.E. The International Consensus on Standardized Nomenclature of Antinuclear Antibody HEp-2 Cell Patterns (ICAP) initiative – Current state and perspectives. In: K. Conrad, E.K.L. Chan, L.E.C. Andrade, G. Steiner, G.J.M. Pruijn, Y. Shoenfeld (eds), From Autoantibody Research to Standardized Diagnostic Assays in the Management of Human Diseases series – Report on the 12th Dresden Symposium on Autoantibodies, Germany, p282-288.
Satoh, M., Tanaka, S., and Chan, E.K. Current status and issues of concern for the diagnostic autoantibody tests. In: K. Conrad, E.K.L. Chan, L.E.C. Andrade, G. Steiner, G.J.M. Pruijn, Y. Shoenfeld (eds), From Autoantibody Research to Standardized Diagnostic Assays in the Management of Human Diseases series – Report on the 12th Dresden Symposium on Autoantibodies, Germany, p298-306.
Chan, E.K., Damoiseaux, J., Carballo, O.G., Conrad, K., de Melo Cruvinel, W., Francescantonio, P.L., Fritzler, M.J., Garcia-De La Torre, I., Herold, M., Mimori, T., Satoh, M., von Mühlen, C.A., and Andrade, L.E. Report of the First International Consensus on Standardized Nomenclature of Antinuclear Antibody HEp-2 Cell Patterns 2014-2015. Front Immunol. 6:412.
Satoh, M., Tanaka, S., and Chan, E.K. The uses and misuses of multiplex autoantibody assays in systemic autoimmune rheumatic diseases. Front Immunol. 6:181.
Fredenburg, K.M. and Chan, E.K. Our journey from the study of human autoantibodies to the microRNA world. Front Immunol. 6:110.
Calise, S.J., Keppeke, G.D., Andrade, L.E., and Chan, E.K. Anti-rods/rings: a human model of drug-induced autoantibody generation. Front Immunol. 6:41.
2014
Satoh, M., Chan, J.Y., Ceribelli, A., and Chan, E.K. Autoantibodies to survival of motor neuron (SMN) complex. In Autoantibodies (Shoenfeld, Y., Meroni, P.L., Gershwin, M.E., Eds.), pp. 139-144. Elsevier Science, Third Edition.
Satoh, M., Fritzler, M.J. and Chan, E.K. Anti-U1RNP and -Sm antibodies. In Autoantibodies (Shoenfeld, Y., Meroni, P.L., Gershwin, M.E., Eds.), pp. 151-159. Elsevier Science, Third Edition.
Fritzler, M.J. and Chan, E.K. Autoantibodies to GW/P bodies and components of the microRNA pathway. In Autoantibodies (Shoenfeld, Y., Meroni, P.L., Gershwin, M.E., Eds.), pp. 257-263. Elsevier Science, Third Edition.
Fritzler, M.J. and Chan, E.K. Golgi complex and endosome antibodies. In Autoantibodies (Shoenfeld, Y., Meroni, P.L., Gershwin, M.E., Eds.), pp. 265-273. Elsevier Science, Third Edition.
Ceribelli, A., Satoh, M., and Chan, E.K. Antinuclear Antibodies: General Introduction. In Autoantibodies, (Shoenfeld, Y., Meroni, P.L., Gershwin, M.E., Eds.), pp. 129-137. Elsevier Science, Third Edition.
Calise, S.J., Carcamo, W.C., Ceribelli, A., Dominguez, Y., Satoh, M., and Chan, E.K. Antibodies to rods and rings. In Autoantibodies (Shoenfeld, Y., Meroni, P.L., Gershwin, M.E., Eds.), pp. 161-168. Elsevier Science, Third Edition.
Carcamo, W.C., Calise, S.J., von Mühlen, C.A., Satoh, M., and Chan, E.K. Molecular cell biology and immunobiology of mammalian rod/ring structures. Int Rev Cell Mol Biol. 308:35-74.
2013
Chan, E.K., Ceribelli, A., and Satoh, M. MicroRNA-146a in autoimmunity and innate immune responses. Ann Rheum Dis. 72:ii90-ii95.
Chan, E.K., Yao, B., and Fritzler, M.J. Reflections on ten years of history of, and future prospects for, GW182 and GW/P body research. In Ten Years of Progress in GW/P Body Research, edited by E.K.L. Chan and M.J. Fritzler, Adv Exp Med Biol, 768:261-70.
Chan, E.K. and Fritzler, M.J. Introduction – The GW body story as an example of autoantibodies with significant impacts to molecular cell biology. In Ten Years of Progress in GW/P Body Research, edited by E.K.L. Chan and M.J. Fritzler, Adv Exp Med Biol, 768:1-4.
Fritzler, M.J. and Chan, E.K. The discovery of GW bodies. In Ten Years of Progress in GW/P Body Research, edited by E.K.L. Chan and M.J. Fritzler, Adv Exp Med Biol, 768:5-21.
Satoh, M., Chan, J.Y., Ceribelli, A., Vazquez del-Mercado, M., and Chan, E.K. Autoantibodies to Argonaute 2 (Su antigen). In Ten Years of Progress in GW/P Body Research, edited by E.K.L. Chan and M.J. Fritzler, Adv Exp Med Biol, 768:45-59.
Yao, B., Li, S., and Chan, E.K. Function of GW182 and GW bodies in siRNA and miRNA pathways. In Ten Years of Progress in GW/P Body Research, edited by E.K.L. Chan and M.J. Fritzler, Adv Exp Med Biol, 768:71-96.
Moser, J.J., Chan, E.K., and Fritzler, M.J. An SNP in the trinucleotide repeat region of the GW182/TNRC6A gene maps to a major TNGW1 autoepitope in patients with autoantibodies to GW182. In Ten Years of Progress in GW/P Body Research, edited by E.K.L. Chan and M.J. Fritzler, Adv Exp Med Biol, 768:243-59.
2012
Satoh, M., Ceribelli, A., and Chan, E.K. Common pathways of autoimmune inflammatory myopathies and genetic neuromuscular disorders. Clin. Rev. Allergy Immunol. 42:16-25.
2011
Chan, E.K., Ceribelli, A., and Nahid, M.A. The role of miRNAs in the regulation of immunological functions and the prevention of autoimmunity. In: K. Conrad, E.K.L. Chan, M.J. Fritzler, R.L. Humbel, P.L. Meroni, Y. Shoenfeld (eds), From Prediction to Prevention of Autoimmune Diseases. Autoantigens, Autoantibodies and Autoimmunity series. Volume 7. Proceedings 10th Dresden Symposium on Autoantibodies. Pabst Science Publishers, Lengerich, Germany, pp253-266.
Ceribelli, A., Nahid, M.A., Satoh, M., and Chan, E.K. MicroRNAs in rheumatoid arthritis. FEBS Letters 585, pp. 3667-3674.
Ceribelli, A., Yao, B., Dominguez-Gutierrez, P.R., and Chan, E.K. Editorial: Lupus T cells switched on by DNA hypomethylation via microRNAs? Arthritis Rheum. 63:1177-81.
Ceribelli, A., Yao, B., Dominguez-Gutierrez, P.R., Nahid, M.A., Satoh, M., and Chan, E.K. MicroRNAs in systemic rheumatic diseases. Arthritis Res. Ther. 13:229.
Nahid, M.A., Satoh, M., and Chan, E.K. MicroRNA in TLR signaling and endotoxin tolerance. Cell. Mol. Immunol. 8:388-403.
2010
Chan, E.K. Autoantibodies to multiple components of the microRNA pathway and aberrant microRNA expression in autoimmune diseases. In: Jack D. Keene (ed), Autoantibodies and Autoimmunity, MBL, Tokyo, Japan, pp45-59.
Satoh, M., Fritzler, M.J., and Chan, E.K. Anti-histone and anti-spliceosomal antibodies. In Systemic Lupus Erythematosus, 5th ed. edited by Robert G. Lahita. Academic Press, San Diego, Chapter 16, pp. 275- 292.
2009
Katz, J. and Chan, E.K. Commentary: Cell cycle proteins to monitor cancer of salivary glands. Cancer Biol. Ther. 8:159-160.
Satoh, M., Vázquez-Del Mercado, M., and Chan, E.K. Clinical interpretation of antinuclear antibody tests in systemic rheumatic diseases. Mod. Rheum. 19:219-28.
Chan, E.K., Satoh, M., and Pauley, K.M. Editorial: Contrast in aberrant microRNA expression in SLE and RA: Is miR-146 all we need? Arthritis Rheum. 60:912-915.
Pauley, K.M., Cha, S., and Chan, E.K. MicroRNA in autoimmunity and autoimmune diseases. J. Autoimmunity 32:189-194.
2008
Pauley, K.M., and Chan, E.K. MicroRNAs and their emerging roles in immunology. In: Noel R. Rose (ed), The Year in Immunology, Ann. N.Y. Acad. Sci. 1143:226-39.
2007
Jakymiw, A., Pauley, K.M., Li, S., Lian, S., Ikeda, K., Eystathioy, T., Satoh, M., Fritzler, M.J., and Chan, E.K. The role of GW/P-bodies in RNA processing and silencing. J. Cell Sci. 120:1317-1323.
Satoh, M., Chan, E.K., Sobel, E.S., Kimpel, D.L., Yamasaki, Y., Narain, S., Mansoor, R., and Reeves, W.H. Clinical implication of autoantibodies in patients with systemic rheumatic diseases. Expert Rev. Clin. Immunol. 3:721-38.
Books
Ten Years of Progress in GW/P Body Research, Dr. Edward K.L. Chan and Dr. Marvin J. Fritzler, Eds.