Dr. Chan’s laboratory has a long history of the identification and characterization of specific autoimmune target antigens in different systemic rheumatic diseases.

GW bodies (GWBs) are cytoplasmic foci initially identified through the use of an autoimmune serum targeting the marker protein GW182.

Since joining the University of Florida, Dr. Chan’s lab has worked on head and neck and oral cancers.

Historically, there have been few examples of human autoantibodies used in elucidating novel subcellular macromolecular complexes and structures.